Evidence map›Paper›PMID 41896509›Full record

ArticleAnnals of surgical oncology2026

Association Between Metabolic Syndrome and Long-Term Prognosis in Patients with Perihilar Cholangiocarcinoma Treated with Curative-Intent Resection: A Multicenter Study.

Zhi-Peng Liu, Zi-Mu Li, Long-Fei Ren, Hai-Su Dai, Yu-Le Luo, Chun-Yue Ye, Zhi-Xin Wang, Xing-Chao Liu, Jie Bai, Yan Jiang and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Zhi-Peng LiuDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
Zi-Mu LiDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), The First Affiliated Hospital of Army Medical University, Army Medical University, Chongqing, China.
Long-Fei RenDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
Hai-Su DaiDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), The First Affiliated Hospital of Army Medical University, Army Medical University, Chongqing, China.
Yu-Le LuoDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), The First Affiliated Hospital of Army Medical University, Army Medical University, Chongqing, China.
Chun-Yue YeDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), The First Affiliated Hospital of Army Medical University, Army Medical University, Chongqing, China.
Zhi-Xin WangDepartment of Hepatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, China.
Xing-Chao LiuDepartment of Hepatobiliary Surgery, Sichuan Provincial People's Hospital, Chengdu, China.
Jie BaiDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), The First Affiliated Hospital of Army Medical University, Army Medical University, Chongqing, China.
Yan JiangDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), The First Affiliated Hospital of Army Medical University, Army Medical University, Chongqing, China.
Zhi-Yu ChenDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), The First Affiliated Hospital of Army Medical University, Army Medical University, Chongqing, China. chenzhiyu_umn@163.com.
Lei ZhangDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China. ldyy_lzhang@lzu.edu.cn.
Biliary Surgery Branch of Elite Group of Chinese Digestive Surgery (EGCDS)

Funding

Gansu Provincial Key R&D Program 24YFFA035General Project of the Joint Research Fund of the Science and Technology Department of Gansu Province 3JRRA1498Natural Science Foundation of Gansu Province 21JR1RA072
6 · The paper itself

Abstract

backgroundMetabolic syndrome (MetS) was linked to poor cancer outcomes, but its impact on perihilar cholangiocarcinoma (pCCA) survival postresection was unclear. In this study, we investigated the association between MetS and long-term prognosis in patients with pCCA after curative-intent resection.

methodsConsecutive patients with pCCA who underwent curative-intent resection at four hospitals (2018-2023) were enrolled and stratified into the MetS and non-MetS groups. Mets was diagnosed when patients met three or more of the following five criteria: (1) body mass index ≥ 25 kg/m

resultsOf the 321 included patients, 78 (24.3%) had MetS. After inverse probability of treatment weighting, the MetS and non-MetS groups comprised 77.30 and 242.21 cases, respectively, with no significant differences in tumor factors (P > 0.05). The MetS group had significantly lower 5-year OS (29.5% vs. 32.9%, P = 0.039), 5-year RFS (18.1% vs. 26.1%, P = 0.025), and 5-year CSS (30.8% vs. 34.8%, P = 0.048). MetS was an independent predictor of worse OS, RFS, and CSS.

conclusionsApproximately 25% of patients with pCCA who underwent curative-intent resection had MetS, which significantly increased early recurrence risk and worsened long-term survival.

Indexed as

Bile Duct NeoplasmsHepatectomyKlatskin TumorMetabolic SyndromeAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateCurative-intent resectionEarly recurrenceLong-term prognosisMetabolic syndromePerihilar cholangiocarcinoma

Identifiers

PMID41896509

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.