ArticleFunctional & integrative genomics2026
A Comparative Single-Cell Atlas Reveals Pre-injury Signatures of Superior Healing in Oral Mucosa and Informing a New Paradigm for Wound Management.
Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Poor surgical wound healing after major surgery could cause serious consequences. Compared to the interventions after complications occur, preoperative assessment and management of tissue healing capacity could optimize outcomes and alleviate patient distress. Notably, oral mucosa heals faster with reduced scarring after injury compared to skin, making it a natural model of superior healing potential. The cellular and molecular networks underlying these divergent healing capacities were valuable to guide the preoperative assessment and management of tissue healing potential. However, these mechanisms have not been fully elucidated due to a lack of comparative studies on healthy homeostatic tissues and the limitation of bulk-RNA sequencing and in vitro experiments in unveiling complex in vivo microenvironments. Herein, single-cell sequencing datasets from healthy oral mucosa and skin were integrated and subjected to comparative analysis as well as in vivo validation to construct a comparative transcriptional atlas. Our results revealed that oral fibroblasts demonstrate higher activation of transcription factors (FOSB, EGR1, FOS, JUNB, JUN, and CEBPB) and transmit distinctive ligand-receptor interactions involving extracellular matrix components and secretory signals that target vascular endothelial cells (ANGPTL, ncWNT, IGF, PTN, MK, LAMININ, COLLAGEN), basal keratinocytes (IGF, MPZ, TENASCIN, MK, COLLAGEN), and immune cells (CXCL, CCL, TGFB). These features are associated with stronger extracellular matrix synthesis capacity and greater capacities of oral fibroblasts in promoting angiogenesis, epithelial regeneration, and creating a pro-healing immune microenvironment. These insights inform a conceptual framework for preoperative assessment and management of tissue’s inherent healing potential to reduce severe complications after major surgeries, potentially shifting the surgical wound management paradigm from post-complication intervention to proactive management.
Indexed as
Identifiers
41896475What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.