Evidence map›Paper›PMID 41896434›Full record

ArticleSleep & breathing = Schlaf & Atmung2026

Long-term effect of continuous positive airway pressure on cardiovascular outcomes after acute myocardial infarction in obstructive sleep apnea patients.

Jaskiran Khosa, Moemen Khattab, Ahmad Adam, Amina Jamali, Nathanael Hwang, Jessica Jara, Matthew Klimper, Jane Lin, Jiaxiao Shi, Dennis Hwang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jaskiran KhosaKaiser Permanente Southern California Inland Empire Internal Medicine Residency Program, Fontana, CA, 92335, USA.
Moemen KhattabKaiser Permanente Southern California Inland Empire Internal Medicine Residency Program, Fontana, CA, 92335, USA.
Ahmad AdamKaiser Permanente Southern California Inland Empire Internal Medicine Residency Program, Fontana, CA, 92335, USA.
Amina JamaliKaiser Permanente Southern California Inland Empire Internal Medicine Residency Program, Fontana, CA, 92335, USA.
Nathanael HwangDepartment of Sleep Medicine, Southern California Permanente Medical Group, Fontana Medical Center, Fontana, CA, 92335, USA.
Jessica JaraDepartment of Sleep Medicine, Southern California Permanente Medical Group, Fontana Medical Center, Fontana, CA, 92335, USA.
Matthew KlimperDepartment of Sleep Medicine, Southern California Permanente Medical Group, Fontana Medical Center, Fontana, CA, 92335, USA.
Jane LinKaiser Permanente Research & Evaluation Department, Pasadena, CA, 91101, USA.
Jiaxiao ShiKaiser Permanente Research & Evaluation Department, Pasadena, CA, 91101, USA.
Dennis HwangDepartment of Sleep Medicine, Southern California Permanente Medical Group, Fontana Medical Center, Fontana, CA, 92335, USA.
Jie RenDepartment of Cardiology, Southern California Permanente Medical Group, Fontana Medical Center, 9961 Sierra Ave, Fontana, CA, 92335, USA. jie.x.ren@kp.org.ORCID http://orcid.org/0009-0005-7302-055X

Funding

Kaiser Permanente Division of Research KP-RRC-20200505
6 · The paper itself

Abstract

purposeObstructive sleep apnea (OSA) is highly prevalent in patients with acute myocardial infarction (AMI), contributing to increased cardiovascular risk. Continuous positive airway pressure (CPAP) is the standard treatment for OSA, yet its long-term role in reducing major adverse cardiac and cerebrovascular events (MACCE) remains controversial. This study evaluates the impact of CPAP adherence on long-term cardiovascular outcomes in post-AMI patients with OSA.

methodsThis retrospective cohort study analyzed electronic health record from Kaiser Permanente Southern California between 2015 and 2019. Adult patients with AMI and a history of OSA were included. Patients were categorized into CPAP-adherent users (≥ 4 h/night; n = 54) and non-adherent users (< 4 h/night; n = 126) during the follow-up period. The primary endpoint was MACCE, a composite of 30-day cardiovascular readmissions, repeat cardiac catheterization, cerebrovascular accident (CVA), congestive heart failure (CHF), recurrent AMI, and mortality. Cox regression models were used to examine the association between CPAP adherence and MACCE.

resultsCPAP adherence was associated with a 51% reduction in MACCE risk (adjusted HR 0.49, 95% CI 0.26–0.92, p = 0.03). Re-catheterization was significantly lower in the CPAP-adherent group (1.9% vs. 11.1%, p = 0.04), while CVA events occurred exclusively in the non-adherent group.

conclusionsAdherent CPAP use is significantly associated with lower cardiovascular risk in post-AMI patients with OSA. These findings highlight the potential value of OSA screening and promoting CPAP adherence as part of secondary prevention strategies following AMI. Further prospective studies are needed to validate these results and refine prevention strategies in high-risk populations.

Indexed as

Cardiovascular DiseasesContinuous Positive Airway PressureMyocardial InfarctionSleep Apnea, ObstructiveAgedFemaleHumansMaleMiddle AgedPatient ComplianceRetrospective StudiesAcute myocardial infarctionContinuous positive airway pressureMajor adverse cardiac and cerebrovascular eventsObstructive sleep apneaSecondary prevention

Identifiers

PMID41896434

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.