Evidence map›Paper›PMID 41896346›Full record

ArticleScientific reports2026

Endogenous and environmental factors that induce DNA replication defects and genomic instability in ER-negative heterozygous BRCA1 cells.

Madhura Deshpande, Theodore Paniza, Rebecca Brown, Kate Heslin, Nitya Patel, Advaitha Madireddy, Zev Rosenwaks, Jeannine Gerhardt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Madhura DeshpandeThe Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 515E 71 st Street, New York, 10021, NY, USA. mgd2002@med.cornell.edu.
Theodore PanizaThe Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 515E 71 st Street, New York, 10021, NY, USA.
Rebecca BrownThe Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 515E 71 st Street, New York, 10021, NY, USA.
Kate HeslinThe Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 515E 71 st Street, New York, 10021, NY, USA.
Nitya PatelThe Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 515E 71 st Street, New York, 10021, NY, USA.
Advaitha MadireddyDepartment of Pediatric Hematology/Oncology, Rutgers University, New Brunswick, NJ, USA.
Zev RosenwaksThe Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 515E 71 st Street, New York, 10021, NY, USA.
Jeannine GerhardtThe Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 515E 71 st Street, New York, 10021, NY, USA. jeg2039@med.cornell.edu.

Funding

Environmental factors and compounds affecting the genomic stability in haploinsufficient BRCA1 cells.R01ES034733 · NIEHS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jeannine Gerhardt · 2023 to 2026
$1.5M
NIEHS NIH HHS R01 ES034733NIEHS NIH HHS R01ES034733
6 · The paper itself

Abstract

Carriers with a germline mutation in the BRCA1 gene have an increased lifetime risk of breast and ovarian cancer and other malignancies. Cancer initiation is linked to mutagenesis and loss of heterozygosity (LOH) in BRCA1 carriers. Approximately 70% of BRCA1-associated breast cancers are triple negative (TNBC; progesterone (PR), HER2, estrogen receptor (ER)-negative), which were reported to develop from ER/PR-negative luminal progenitor cells. However, the mechanisms and factors inducing carcinogenesis in ER/PR-negative cells carrying a BRCA1 germline mutation are not known. Also, ER/PR-negative breast cancer cells are not responsive to ER hormone therapy, making it challenging to treat TNBC cancers. We investigated ER-negative mammary cells and found that estrogen and estrogen metabolites, which are known to form DNA adducts, inhibit replication fork progression in heterozygous BRCA1

Indexed as

BRCA1 ProteinDNA ReplicationGenomic InstabilityReceptors, EstrogenAnimalsCell Line, TumorEstrogensFemaleHeterozygoteHumansLoss of HeterozygosityBRCA1 ProteinBRCA1 protein, humanEstrogensReceptors, Estrogen

Identifiers

PMID41896346
PMCPMC13039430

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.