Observational studyScientific reports2026
pH profiling reveals progressive wound acidification during healing and higher pH in chronic non-healing wounds: a prospective, multicenter cohort study.
Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.Bioactive materials · 2027Review
- Acidic and alkaline conditions enhance Staphylococcus aureus α-toxin pore formation and cytotoxicity.PLoS pathogens · 2026Article
- Smart Polymeric Wound Dressings for Wound Treatment: Contributions and Applications.International journal of molecular sciences · 2026Review
- Lactoferrin Displays Stimulating and Protective Effects on Newly Isolated Phage vB_Sau-E: A New Perspective for Treatment of Staphylococcal Skin Infections.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Plasma-activated water: a dual-action disinfectant and wound-healing therapy for diabetes-related foot infections.FEMS microbiology reviews · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The local microenvironment of wounds plays a crucial role in healing, with pH and temperature emerging as promising biomarkers. This prospective, multi-center, observational study assessed pH and temperature in acute and chronic wounds to identify physicochemical patterns associated with healing. A total of 117 patients with various wound etiologies underwent 226 pH and 181 temperature measurements at the wound center, edge, and surrounding skin. With a pH of 7.113 ± 0.659 and 7.043 ± 0.694, chronic and non-healing wounds exhibited significantly higher pH values than acute (6.592 ± 0.617) and healing wounds (6.820 ± 0.814; p<.05), with the wound center showing the largest difference (ΔpH = 0.52). A pH gradient was observed, decreasing from wound center to surrounding skin. Longitudinal analysis revealed a weekly pH decline of 0.05 units in healing wounds. Temperature showed a similar downward trend over time, though differences between groups were less pronounced. These findings indicate that progressive acidification of the wound environment correlates with healing, while alkaline pH is associated with chronicity and infection. Local pH, more so than temperature, may serve as a non-invasive, dynamic biomarker for wound monitoring and as a potential therapeutic target. Further interventional studies are warranted to evaluate pH-monitoring and potential modulation by wound therapies.
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