Evidence map›Paper›PMID 41896269›Full record

ArticleScientific reports2026

Chromatin dynamics of the Klf4 locus in mouse pluripotent cells.

Jente van Staalduinen, Hélène Kabbech, Selçuk Yavuz, Ridvan Cetin, Agnese Loda, Wiggert van Cappellen, Adriaan Houtsmuller, Kerstin Wendt, Ihor Smal, Frank Grosveld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jente van StaalduinenFormer Department of Cell Biology, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6790-8345
Hélène KabbechFormer Department of Cell Biology, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9200-2112
Selçuk YavuzDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4816-4154
Ridvan CetinFormer Department of Cell Biology, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands.ORCID http://orcid.org/0009-0000-5743-8888
Agnese LodaDirectors' Research, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8109-128X
Wiggert van CappellenErasmus Optical Imaging Centre, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9059-8365
Adriaan HoutsmullerDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0967-0740
Kerstin WendtFormer Department of Cell Biology, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0235-1237
Ihor SmalFormer Department of Cell Biology, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7576-7028
Frank GrosveldFormer Department of Cell Biology, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands. f.grosveld@erasmusmc.nl.ORCID http://orcid.org/0000-0002-7051-4715

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 737.016.014
6 · The paper itself

Abstract

Understanding the factors involved in chromatin dynamics is crucial for the study of biochemical processes in which distant genomic regions need to come in close proximity. Previous single locus tracking studies suggest that chromatin dynamics are linked to active transcription, but studies which compare the chromatin dynamics between different locations within a defined chromatin domain are still very limited. Here we used the ANCHOR3 DNA labeling system to track multiple cis-regulatory elements and non-regulatory control regions at different positions in the mouse Klf4 locus. We observe homogeneous chromatin motion of cis-regulatory elements and non-regulatory control regions in Klf4 transcribing mESCs and their non-transcribing EpiLCs daughter cells. These observations challenge the notion that active transcription has a major effect on the locus dynamics of mammalian genes.

Indexed as

ChromatinGenetic LociKruppel-Like Transcription FactorsPluripotent Stem CellsAnimalsKruppel-Like Factor 4MiceRegulatory Sequences, Nucleic AcidTranscription, GeneticChromatinKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsANCHOR DNA labelingChromatin dynamicsKlf4Rad23bSingle locus tracking

Identifiers

PMID41896269
PMCPMC13039108

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.