Evidence map›Paper›PMID 41895857›Full record

ArticleeNeuro2026

Parvalbumin Neuron-Targeted Loss of Alzheimer's Disease Risk Gene

M Natalie Davis, Mary Bullock, Aanishaa Jhaldiyal, Niya Holifield, Karim Mikhail, Yuliya Voskobiynyk, Rachael M Vollmer, George C Prendergast, Kelli Lauderdale, Jorge J Palop and 2 more

Abstract read
In one paragraph

Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M Natalie DavisDepartment of Neurology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294.ORCID 0000-0002-2296-7605
Mary BullockDepartment of Neurology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294.
Aanishaa JhaldiyalDepartment of Neurology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294.
Niya HolifieldDepartment of Psychiatry, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294.
Karim MikhailDepartment of Neurology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294.
Yuliya VoskobiynykDepartment of Neurology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294.ORCID 0000-0003-4169-3002
Rachael M VollmerDepartment of Neurology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294.
George C PrendergastLankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096.
Kelli LauderdaleGladstone Institute of Neurological Disease, San Francisco, California 94158.
Jorge J PalopGladstone Institute of Neurological Disease, San Francisco, California 94158.
Karen L GambleAlzheimer's Disease Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294.
Erik D RobersonDepartment of Neurology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294 eroberson@uabmc.edu.ORCID 0000-0002-1810-9763

Funding

UAB Alzheimer's Disease Research CenterP30AG086401 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erik D Roberson · 2024 to 2026
$17.1M
UAB Research Training Program in Neurobiology of Cognition and Cognitive DisordersT32NS061788 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Farah Dominique Lubin · 2008 to 2026
$4.5M
Circadian changes in network excitability and Alzheimer disease pathogenesisR01AG061785 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAMBLE, KAREN L, ROBERSON, ERIK D · 2021 to 2025
$3.9M
BIN1, Interneuron Activity, and Network Dysfunction in Alzheimer DiseaseRF1AG059405 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROBERSON, ERIK D · 2018 to 2018
$2.6M
NIA NIH HHS P30 AG086401NIA NIH HHS R01 AG061785NIA NIH HHS RF1 AG059405NINDS NIH HHS T32 NS061788
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptor Proteins, Signal TransducingAlzheimer DiseaseBrainCognitionNeuronsNuclear ProteinsParvalbuminsTumor Suppressor ProteinsAnimalsDisease Models, AnimalElectroencephalographyExploratory BehaviorFemaleMaleMiceMice, KnockoutAdaptor Proteins, Signal TransducingBin1 protein, mouseNerve Tissue ProteinsNuclear ProteinsParvalbuminsTumor Suppressor ProteinsAlzheimer's diseaseBIN1network hyperexcitabilityparvalbumin

Identifiers

PMID41895857
PMCPMC13064429

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.