Observational studyBrazilian journal of otorhinolaryngology
Prognostic factors analysis of patients with oral cavity squamous cell carcinoma.
Observational study in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Potential Years of Life Lost Due to Lip, Oral and Oropharyngeal Cancer in Brazil: Estimates and Forecasting.International dental journal · 2026Article
- Can we now save the neck of OSCC T1-T2 patients? A narrative review of whether experimental techniques are on the way to clinical application.Exploration of targeted anti-tumor therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to analyze prognostic factors associated with survival and recurrence in patients with Oral Cavity Squamous Cell Carcinoma (OCSCC) treated in São Paulo, Brazil. The investigation focused on evaluating the influence of clinical stage, treatment modality, age, and sex on overall and recurrence-free survival in a large cohort derived from a public cancer registry. STUDY
designSingle-center retrospective observational study with a cross-sectional and quantitative design.
settingSão Paulo, Brazil.
methodsA retrospective analysis was conducted using data from 10,122 patients diagnosed with OCSCC between 2004 and 2014, obtained from the Oncocenter Foundation of São Paulo (FOSP) database. The primary endpoint was Overall Survival (OS), and secondary endpoints included Recurrence-Free Survival (RFS), Disease-Free Survival (DFS), and Local Recurrence-Free Survival (LRFS). Prognostic factors were assessed through univariable and multivariable Cox proportional hazards models. Kaplan-Meier curves were used to estimate survival, and comparisons were made using the log-rank test.
resultsThe mean follow-up time was 39.37 ± 37.93 months. Age ranged from 11- to 104-years, with a mean age of 60.2 ± 12.6 years at diagnosis, and 78.3% were male. Most patients (61.97%) were diagnosed at an advanced stage (III-IV). Advanced stage and non-surgical treatment were independently associated with worse OS (HR = 4.253, 95% CI 3.883-4.659; 2.546, 95% CI 2.381-2.722, respectively). The 5-year overall survival rate was 50.3%, with a mean survival interval of 6.70 ± 0.06 years after diagnosis. Elderly patients and men had higher recurrence and mortality risks, whereas early-stage disease and surgical treatment were associated with better outcomes.
conclusionAdvanced clinical stage and non-surgical treatment were the strongest independent prognostic factors for decreased survival in OSCC. These findings underscore the importance of early detection and surgical management, as well as the need for public health strategies to reduce diagnostic and treatment delays in Brazil. LEVEL OF EVIDENCE: 2B.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.