Evidence map›Paper›PMID 41894644›Full record

ArticleThe Journal of urology2026

Baseline Urinary Calcium and the Efficacy of Thiazide Diuretics for Kidney Stone Prevention.

Ryan S Hsi, Phyllis L Yan, Joseph J Crivelli, Pietro Manuel Ferraro, Gary C Curhan, Sarah Best, John R Asplin, Vahakn Shahinian, John M Hollingsworth

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Article in The Journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ryan S HsiDepartment of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0003-1652-694X
Phyllis L YanDow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan.
Joseph J CrivelliDepartment of Urology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
Pietro Manuel FerraroSection of Nephrology, Department of Medicine, Università degli studi di Verona, Verona, Italy.
Gary C CurhanChanning Division of Network Medicine, Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Sarah BestDepartment of Urology, University of Wisconsin, Madison, Wisconsin.
John R AsplinLitholink Corporation, Laboratory Corporation of America Holdings, Itasca, Illinois.
Vahakn ShahinianDow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan.
John M HollingsworthDepartment of Urology, University of Florida College of Medicine, Gainesville, Florida.

Funding

Real-world effectiveness of preventive pharmacological therapy for patients with kidney stonesR01DK121709 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLLINGSWORTH, JOHN MALCOLM, SHAHINIAN, VAHAKN B · 2020 to 2024
$3.0M
NIDDK NIH HHS R01 DK121709
6 · The paper itself

Abstract

purposePrevious studies have shown that thiazide diuretics' ability to decrease symptomatic stone events depends on the extent to which they reduce urine calcium. However, it remains unknown whether the calcium change from thiazide diuretics depends on the baseline urine calcium level. MATERIALS AND

methodsAmong a cohort of Medicare beneficiaries with a 24-hour urine collection for kidney stone disease processed by Labcorp/Litholink between 2011 and 2018, we identified a subset aged > 18 years newly prescribed a thiazide diuretic who performed a second collection between 30 and 180 days after their initial prescription fill. We then fit multivariable linear regression models to estimate the association between dose of thiazide prescribed and change in urine calcium, stratifying by baseline urine calcium. We compared cumulative incidences of clinical stone events stratified by baseline urine calcium groups within a treated and untreated cohort.

resultsFrom a total of 634 participants, higher baseline urine calcium was associated with greater 24-hour mean absolute (in mg/d) and percentage urine calcium reductions (

conclusionsGreater urine calcium reductions after thiazide treatment are observed among those with higher baseline urine calcium, and higher thiazide dose led to a larger reduction. These data are relevant for individualizing thiazide dose for kidney stone prevention.

Indexed as

CalciumKidney CalculiSodium Chloride Symporter InhibitorsAgedFemaleHumansIncidenceMaleTreatment OutcomeUnited StatesCalciumSodium Chloride Symporter Inhibitorssecondary preventionthiazidesurolithiasis

Identifiers

PMID41894644
PMCPMC13041727

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.