Evidence map›Paper›PMID 41894506›Full record

ArticleScience advances2026

EnvZ/OmpR-driven cooperative behavior promotes cefiderocol resistance in a hanging-droplet evolution system.

Bowen Li, Kaiwen Song, Qi Wang, Xu Gao, Ruobing Wang, Shitao Shen, Wei Wang, Hui Wang

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bowen LiDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China.ORCID 0009-0008-2558-1688
Kaiwen SongDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China.ORCID 0009-0005-8021-5945
Qi WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China.ORCID 0009-0005-0269-8435
Xu GaoSchool of Integrated Circuits, Peking University, Beijing 100871, The People's Republic of China.
Ruobing WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China.ORCID 0000-0002-9921-7271
Shitao ShenSchool of Integrated Circuits, Peking University, Beijing 100871, The People's Republic of China.ORCID 0000-0001-5945-2173
Wei WangSchool of Integrated Circuits, Peking University, Beijing 100871, The People's Republic of China.ORCID 0000-0002-5257-7675
Hui WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China.ORCID 0000-0001-9220-0357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding how bacteria rapidly adapt to recently introduced antibiotics increasingly demands experimental models that move beyond classical evolution systems. We developed a microbial evolution hanging-droplet system (MEHS) that uses gravity-driven flow to sustain continuous exponential growth, doubling daily reproduction rate. Using this MEHS,

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCephalosporinsDrug Resistance, BacterialKlebsiella pneumoniaeCefiderocolEvolution, MolecularMutationAnti-Bacterial AgentsBacterial ProteinsCefiderocolCephalosporins

Identifiers

PMID41894506
PMCPMC13025041

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.