Evidence map›Paper›PMID 41894428›Full record

ArticleProteomics2026

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple-Negative Breast Cancer Progression.

Ha-Song Bae, Yun-Jeong Seo, Eun-Bi Kim, Hyoung-Min Park, I-Hsuan Liu, J Eugene Lee, Jae-Young Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ha-Song BaeGraduate School of Analytical Science and Technology (GRAST), Chungnam National University, Daejeon, Republic of Korea.
Yun-Jeong SeoGraduate School of Analytical Science and Technology (GRAST), Chungnam National University, Daejeon, Republic of Korea.
Eun-Bi KimGraduate School of Analytical Science and Technology (GRAST), Chungnam National University, Daejeon, Republic of Korea.
Hyoung-Min ParkBiometrology group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea.ORCID 0000-0001-7397-8286
I-Hsuan LiuDepartment of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan (R.O.C.).ORCID 0000-0002-4524-3263
J Eugene LeeBiometrology group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea.
Jae-Young KimGraduate School of Analytical Science and Technology (GRAST), Chungnam National University, Daejeon, Republic of Korea.ORCID 0000-0001-6700-1372

Funding

Chungnam National University Research GrantKorea Research Institute of Standards and ScienceMinistry of Science and ICTNational Research Foundation of Korea RS-2024-00454838National Research Foundation of Korea RS-2025-23525555National Research Foundation of Korea RS-2025-25411966National Research Foundation of Korea RS-2025-25442707
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)-targeting DNA aptamer AS1411 using label-free quantitative proteomic profiling. AS1411 treatment significantly reduced TNBC cell viability and migration. To uncover the underlying mechanisms, we performed global proteomic analysis of AS1411-treated TNBC cells. Bioinformatic analysis of differentially expressed proteins (DEPs) revealed enrichment of tumor-associated signaling pathways and protein-protein interaction networks regulated by AS1411. Among the DEPs, ATPase H

Indexed as

ProteomeTriple Negative Breast NeoplasmsCell Line, TumorCell MovementCell ProliferationCell SurvivalDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansNucleolinProtein Interaction MapsProteomicsRNA-Binding ProteinsNucleolinProteomeRNA-Binding ProteinsAS1411ATP6AP1proteomicstriple‐negative breast cancer

Identifiers

PMID41894428
PMCPMC13327712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.