Evidence map›Paper›PMID 41894400›Full record

ArticlePLoS biology2026

Social compatibility in opposite-sex prairie vole pairs is modulated by early-life sleep experience.

Lezio S Bueno-Junior, Noah E P Milman, Carolyn E Jones-Tinsley, Anjesh Ghimire, Peyton T Wickham, Yujia Hu, Bing Ye, Miranda M Lim, Brendon O Watson

Abstract read
In one paragraph

Article in PLoS biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Social attachment shapes interbrain synchrony.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lezio S Bueno-JuniorDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.ORCID https://orcid.org/0000-0002-8530-8105
Noah E P MilmanPortland VA Research Foundation, Portland, Oregon, United States of America.
Carolyn E Jones-TinsleyPortland VA Research Foundation, Portland, Oregon, United States of America.
Anjesh GhimireDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Peyton T WickhamPortland VA Research Foundation, Portland, Oregon, United States of America.
Yujia HuLife Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America.
Bing YeLife Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America.
Miranda M LimPortland VA Research Foundation, Portland, Oregon, United States of America.
Brendon O WatsonDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

Funding

Effects of early life sleep disruption on prefrontal cortex electrophysiological state and affiliation/attachmentRF1MH131592 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIM, MIRANDA M, WATSON, BRENDON O · 2025 to 2025
$2.0M
Molecular regulators of GABAergic systems that underlie comorbidities in Down syndromeR01NS137222 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joanna H Mattis, BING YE · 2024 to 2026
$1.5M
NIMH NIH HHS RF1 MH131592NINDS NIH HHS R01 NS137222
6 · The paper itself

Abstract

Studies of human social behavior indicate stronger social affinity in matched-neurotype dyads (e.g., two individuals with autism or two without) compared to mixed-neurotype dyads (e.g., one individual with autism paired with one without). Is this dyad matching phenomenon also quantifiable in nonhuman animals? Using deep learning tools, we analyzed dyadic male-female interactions in prairie voles, a socially monogamous rodent species. To simulate "neurotypes", voles were exposed to either control conditions or early-life sleep disruption (ELSD) during a critical neurodevelopmental period (post-natal days 14-21), recapitulating the influence of developmental sleep quality on later-life social behavior. Analogous to human studies, voles showed signs of reduced social affinity in mixed dyads compared to matched dyads, including sex-specific changes in aggression and body orientation toward the conspecific. These findings advance our understanding of social affinity between potential partners, providing a framework for new studies in both animal models and humans.

Indexed as

ArvicolinaeSleepSocial BehaviorAggressionAnimalsBehavior, AnimalFemaleMale

Identifiers

PMID41894400
PMCPMC13043049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.