Trial reportMedicine2026
Effect of normal saline and half saline preservation serums on sodium levels, blood pressure, and acidosis in PICU patients.
Trial report in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the differential effects of normal saline (N/S) (0.9% sodium chloride) and half saline (H/S) (0.45% sodium chloride) preservation solutions on sodium levels, blood pressure, and acid-base balance in critically ill pediatric patients.
methodsA double-blind interventional clinical trial involving 88 pediatric patients was conducted in the pediatric intensive care unit. Patients were randomly assigned to receive either N/S (Group A) or H/S (Group B). Sodium, potassium, chloride, bicarbonate, pH, and blood pressure were measured at baseline and 6, 24, 48, and 72 hours. The primary outcome was the change in serum sodium concentration, and secondary outcomes included blood pressure and acid-base status.
resultsAt 72 hours, sodium levels were significantly higher in the N/S group (137.63 ± 2.99 mEq/L) compared to the H/S group (135.33 ± 2.46 mEq/L; P = .007). Blood pressure was significantly higher in the N/S group at 24 hours (98.78 ± 8.08 mm Hg vs 92.70 ± 9.24 mm Hg; P = .002). No significant differences were observed in potassium levels, pH, or bicarbonate concentrations. The incidence of hyponatremia at 72 hours was similar in both the groups (15.9% for N/S vs 13.6% for H/S).
conclusionNormal saline administration resulted in higher sodium levels and increased systolic blood pressure than H/S administration. These findings underscore the importance of tailored fluid therapy in critically ill pediatric patients, highlighting the potential effects of fluid choice on sodium balance and hemodynamics.
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