SynthesisMedicine2026
Effects of early renal replacement therapy on the outcomes of critically ill patients with acute kidney injury: A systematic review and meta-analysis.
Synthesis in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis meta-analysis aimed to evaluate the efficacy of early renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI).
methodsKeywords included early initiation, AKI, and RRT. The inclusion criteria were based on the population, intervention, comparator, outcomes, and study designs. An electronic search was conducted, and the following databases were used: PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, and ClinicalTrials.gov. The primary outcome was 28-day mortality.
resultsTwenty six studies were eligible for this meta-analysis. The pooled 28-day mortality in 25 studies was 44.7% (1770/3956) and 47.8% (1851/3875) in early and late RRT groups, respectively, and a significant difference was observed between groups (risk ratios [RR] = 0.81; 95% confidence intervals [CI] = 0.72-0.91; I2 = 73%). No significant difference was observed in RRT dependence rate (RR = 1.21; 95% CI = 0.99-1.49; I2 = 28%), recovery of renal function (RR = 1.35; 95% CI = 0.99-1.84; I2 = 91%), and duration of RRT (standard error of the mean = 0.23; 95% CI = -0.94-1.40; I2 = 99%). Subgroup analyses showed that early RRT was associated with lower mortality in surgical patients (RR = 0.60; 95% CI = 0.44-0.80; I2 = 74%) and in single-center settings (RR = 0.64; 95% CI = 0.52-0.79; I2 = 64%).
conclusionsFor critically ill patients with AKI, early initiation of RRT can reduce 28-day mortality by 19% (relative risk reduction of 19%, absolute risk reduction of 3.1%) compared to late initiation, a statistically significant difference. However, clinicians should be alert to the possible adverse effect such as hypotension, catheter-related infection, and hypophosphatemia of early RRT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.