ArticleEmerging microbes & infections2026
A potent Gc neutralizing antibody reveals architecture-dependent bispecific protection against SFTSV.
Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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21 authors.
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Abstract
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a mortality rate of up to 30%. Currently, there are no approved vaccines or therapeutics for clinical use. Although neutralizing antibodies against the viral glycoprotein Gn have been reported, their efficacy can be limited by epitope inaccessibility and viral escape. Here, we isolated human monoclonal antibodies from convalescent donors and identified multiple neutralizing antibodies targeting the Gc glycoprotein, including CAV-Gc-2H1, which binds a previously undefined epitope in Gc domain II and exhibits strong neutralizing activity. To enhance breadth and potency, we engineered bispecific antibodies (bsAbs) that co-engage Gn and Gc. Across several architectural formats, scFv-Ig bsAbs exhibited synergistic neutralization
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