Evidence map›Paper›PMID 41894101›Full record

ArticleAging clinical and experimental research2026

The association between radiographic osteosarcopenia and overall mortality among older patients undergoing colorectal cancer resection.

Efthymios Papadopoulos, Brian A Irving, Heather C M Allaway, Guillaume Spielmann, MingDe Lin, Kelly R Finan

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Article in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Efthymios PapadopoulosSchool of Kinesiology, Louisiana State University, Baton Rouge, LA, USA. epap@lsu.edu.
Brian A IrvingSchool of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
Heather C M AllawaySchool of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
Guillaume SpielmannSchool of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
MingDe LinDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Kelly R FinanOur Lady of the Lake Medical Center, Baton Rouge, LA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteosarcopenia based on computed tomography (CT) is gaining attention as a predictor of adverse outcomes in older adults with cancer.

aimsWe examined whether preoperative radiographic osteosarcopenia was associated with overall mortality (OM) among older patients with colorectal cancer (CRC).

methodsData of older patients (aged ≥ 60 years) who had undergone CRC surgery between October 2018 and February 2024 were retrospectively analyzed. A preoperative abdominal CT scan was used to assess skeletal muscle index (SMI) (cm2/m2) and vertebral bone density (VBD) in Hounsfield units. Patients were assigned into the following categories according to their VBD and SMI status: (i) normal VBD and SMI; (ii) low VBD only; (iii) low SMI only; or (iv) radiographic osteosarcopenia defined as the combination of low VBD and low SMI. The associations between radiographic osteosarcopenia and overall mortality were examined using survival analysis.

resultsIn total, 235 older patients (mean age: 71.8 years) were included in the analysis. Of the 235 patients, 90 (38.3%) had normal VBD and SMI, 28 (11.9%) had low VBD alone, 75 (31.9%) had low SMI alone, and 42 (17.9%) had radiographic osteosarcopenia based on low VBD and low SMI. In multivariable analysis, radiographic osteosarcopenia was associated with a significantly higher risk of OM (hazard ratio (HR): 3.43, 95%CI: 1.42–8.23, p = 0.006) compared to normal VBD and SMI status. Low VBD alone or low SMI alone were not significantly associated with OM.

conclusionsRadiographic osteosarcopenia is significantly associated with OM in older patients undergoing CRC surgery.

Indexed as

Colorectal NeoplasmsSarcopeniaAgedAged, 80 and overBone DensityColorectal Surgical ProceduresFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedCancerColorectal cancerComputed tomographyMortalityOsteoporosisOsteosarcopeniaPostoperative complicationsSarcopeniaSurgery

Identifiers

PMID41894101
PMCPMC13197367

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