ArticleTomography (Ann Arbor, Mich.)2026
Axial X-Ray Microscopy in Nanotomography.
Article in Tomography (Ann Arbor, Mich.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
BACKGROUND/
objectivesThis article develops theory and methods for 3D tomographic imaging of absorption coefficient distributions using axial scanning with EUV microscopes at 46× and 345× magnification. Unlike conventional CT that requires sample rotation, axial scanning moves cells through the microscope focus. The aim is tomographic reconstruction of living cell fine structure without the organelle staining used in optical fluorescence microscopy or ultra-thin cell slicing as in electron microscopy.
methodsBy generalizing the geometric-optical approximation for small absorption coefficient inhomogeneities in absorbing media, we derived a new explicit tomography equation and solution algorithm validated through numerical simulation. The approach was applied to
resultsThe developed methods resolve subcellular features down to 140 nm using the ×46 microscope and 50 nm using the ×345 microscope. Thin low-contrast intracellular structures and individual 50-100 nm organelles were detected.
conclusionsMethods for retrieving absorption coefficient distributions in cone-beam geometry based on geometric-optical theory generalization and on calibration by gold nanoparticles have been developed and validated through numerical simulation and cell analysis. These methods demonstrate for the first time the effectiveness of axial nanotomography using multilayer mirror microscopes for cell diagnostics.
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