Evidence map›Paper›PMID 41893529›Full record

ArticleToxics2026

Evaluating Toxicity and Anti-Osteogenic Activity of Artemisinin-Inspired Endoperoxides in Zebrafish Larvae.

Yaryna S Buzan, Gil Martins, Bruno M S Ferreira, Inês C C Costa, Maria L S Cristiano, Paulo J Gavaia

Abstract read
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaryna S BuzanCentro de Ciências do Mar do Algarve (CCMAR/CIMAR-LA), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal.ORCID 0009-0008-3543-1763
Gil MartinsCentro de Ciências do Mar do Algarve (CCMAR/CIMAR-LA), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-1344-2954
Bruno M S FerreiraCentro de Ciências do Mar do Algarve (CCMAR/CIMAR-LA), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal.
Inês C C CostaCentro de Ciências do Mar do Algarve (CCMAR/CIMAR-LA), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal.ORCID 0000-0003-2711-5441
Maria L S CristianoCentro de Ciências do Mar do Algarve (CCMAR/CIMAR-LA), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-9447-2855
Paulo J GavaiaCentro de Ciências do Mar do Algarve (CCMAR/CIMAR-LA), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-9582-1957

Funding

CRESC Algarve 2020 and COMPETE 2020 EMBRC.PT ALG-01-0145-FEDER-022121Fundação para a Ciência e Tecnologia 2023.04904.BDANAFundação para a Ciência e Tecnologia LA/P/0101/2020Fundação para a Ciência e Tecnologia SFRH7BD70824272020Fundação para a Ciência e Tecnologia UID/04326/2025Fundação para a Ciência e Tecnologia UID/PRR/04326/2025
6 · The paper itself

Abstract

Endoperoxide-containing molecules based on the antimalarial drug artemisinin have demonstrated various biological properties, including modulation of calcium homeostasis. This study evaluated the toxicity and osteogenic activity of five newly developed tetraoxanes (YB1, YB9, YB11, YB17 and T2), alongside three of their non-peroxidic analogues (IC22, IC26 and IC33), in zebrafish (

Indexed as

artemisininCa2+-ATPasecalcium homeostasisendoperoxidesosteogenic activityPfATP6SERCAzebrafish larvae

Identifiers

PMID41893529
PMCPMC13030048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.