Evidence map›Paper›PMID 41893502›Full record

ArticleToxics2026

PPARα Antagonism Rescues Chlorpyrifos-Induced Neuro-Visual Toxicity in Zebrafish (

Yuyao Jiang, Zijie Ding, Ruolin Hu, Jason T Magnuson, Shiyan Li, Dingnan Wang, Shengli Zhou, Yirong Guo, Yang Wang, Yuanyuan Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuyao JiangInstitute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Zijie DingInstitute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Ruolin HuInstitute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Jason T MagnusonDepartment of Environmental Sciences, University of California, Riverside, Riverside, CA 92521, USA.ORCID 0000-0001-6841-8014
Shiyan LiZhejiang Fisheries Technical Extension Center, Hangzhou 310023, China.
Dingnan WangZhejiang Fisheries Technical Extension Center, Hangzhou 310023, China.
Shengli ZhouEcological and Environmental Monitoring Center of Zhejiang Province, Hangzhou 310012, China.
Yirong GuoInstitute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-5262-1675
Yang WangZhejiang Fisheries Technical Extension Center, Hangzhou 310023, China.
Yuanyuan LiuInstitute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Shuying LiInstitute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-0786-5931
Wenjun GuiInstitute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.

Funding

This work was supported by the Zhejiang Provincial 'Lingyan' Research and Development Program No. 2023C02039
6 · The paper itself

Abstract

With the global population predicted to reach 10 billion by 2050, pesticides are essential for agricultural production. However, they can introduce chemical stressors into aquatic ecosystems. Chlorpyrifos (CPF) is a widely used organophosphate insecticide that can enter aquatic environments and poses potential risks to early-life-stage fish. Because the retina is an extension of the central nervous system and vision-guided behaviors are highly sensitive to neural dysfunction, we hypothesized that CPF exposure disrupts neurobehavioral and visual function via oxidative stress and PPARα-related signaling. Zebrafish larvae were exposed to CPF (0.01, 0.1, 1, 10, and 100 μg/L) with a vehicle control (VC). During the photomotor response assay, exposure to 100 μg/L CPF reduced overall swimming activity by 48.90% and dark-period activity by 57.71%, whereas 1 μg/L CPF modestly increased total distance by 6.96% (

Indexed as

behaviorchlorpyrifosomicsperoxisome proliferator-activated receptortoxic optic neuropathy

Identifiers

PMID41893502
PMCPMC13029991

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.