Evidence map›Paper›PMID 41893477›Full record

ArticleToxics2026

Per- and Polyfluoroalkyl Substances (PFAS) in Michigan: A Novel High-Throughput Method with Liquid Chromatography-Mass Spectrometry (LC-MS/MS) Analysis of 42 PFAS Compounds in Human and Bovine Serum.

Jessica M Morrison, Douglas J Carmack, Sarah Y Lockwood-O'Brien, Chelsea A Bielicki, Julia R Feeley, Robert L Frisk, Timothy A Karrer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica M MorrisonBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.ORCID 0000-0001-8186-8036
Douglas J CarmackBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.
Sarah Y Lockwood-O'BrienBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.ORCID 0009-0007-3926-589X
Chelsea A BielickiBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.
Julia R FeeleyBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.
Robert L FriskBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.
Timothy A KarrerBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel method for the analysis of per- and polyfluoroalkyl substances (PFAS) in serum is presented here, utilizing a matrix-matched calibration curve, small sample size, high-throughput sample prep with a protein crash and filtration, resulting in a concentrated and purified sample, which is analyzed via liquid chromatography (LC) mass spectrometry (MS, LC-MS/MS). As part of the validation of this method, accuracy, precision, reportable range verification, sensitivity, carryover, recovery, specificity, interferences, maximum dilutions, and stability are presented. This method quantitates 42 PFAS compounds across a wide variety of compound classes and has limits of detection in the low ng L

Indexed as

analytical sample preparation methodsbiological monitoringenvironmental monitoringfluorocarbonsliquid chromatography–mass spectrometryserum

Identifiers

PMID41893477
PMCPMC13030439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.