Evidence map›Paper›PMID 41893350›Full record

ArticleMetabolites2026

Dietary Citrus Peel Supplementation Enhances Hepatic Energy Metabolism, Muscle 9-HODE Generation and Isoleucine Catabolism in Beef Cattle.

Susumu Muroya, Koichi Ojima, Arata Banno, Hirotaka Nagai, Kazumasa Kakibuchi, Takuma Higuchi, Shuji Sakamoto, Kazutsugu Matsukawa

Abstract read
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Susumu MuroyaDepartment of Animal Science and Welfare, Kagoshima University, Korimoto 890-0065, Kagoshima, Japan.ORCID 0000-0002-2376-9352
Koichi OjimaDivision of Animal Products Research, NARO Institute of Livestock and Grassland Science (NILGS), Tsukuba 305-0901, Ibaraki, Japan.
Arata BannoDepartment of Agriculture and Marine Science, Kochi University, Nankoku 783-8502, Kochi, Japan.ORCID 0000-0002-7041-6605
Hirotaka NagaiDepartment of Agriculture and Marine Science, Kochi University, Nankoku 783-8502, Kochi, Japan.
Kazumasa KakibuchiShikoku Research Institute Inc., Nishimachi, Takamatsu 761-0192, Kagawa, Japan.
Takuma HiguchiScience Research Center, Kochi University, Nankoku 783-8505, Kochi, Japan.
Shuji SakamotoScience Research Center, Kochi University, Nankoku 783-8505, Kochi, Japan.
Kazutsugu MatsukawaDepartment of Agriculture and Marine Science, Kochi University, Nankoku 783-8502, Kochi, Japan.

Funding

Japan Racing Association 2021-21Japan Society for the Promotion of Science 25K02159
6 · The paper itself

Abstract

backgroundCitrus components potentially suppress adipogenic differentiation and lipid accumulation, and exhibit anti-inflammatory and antioxidant effects. We hypothesized that the bioactive compounds in

methodsJapanese Brown (JBR) steers were fed with a diet supplemented with 2.5% yuzu peel during the last month of the finishing period. To investigate the effect of dietary yuzu supplementation (DYS) on beef and liver metabolism, we explored the metabolomic profiles of

resultsThe DYS treatment enhanced the beef fat score compared to that recorded in beef in the no-DYS (None) group (

conclusionCollectively, yuzu ingredients activated ATP production in the liver through the elevation of hepatic energy metabolism primarily in the citrate cycle and β-oxidation, and potentially altered muscle metabolism, including linoleic acid oxidation, FAD-mediated electron transport chain, and isoleucine catabolism, as demonstrated in the reduced accumulation of 2-EHAA and CoQ10 in DYS beef. Moreover, DYS likely affects the gut microbiome by enhancing the production of cyclo(-Leu-Pro), an antimicrobial dipeptide.

Indexed as

bovinecitrusfatty acid oxidationmetabolomicspostmortem agingskeletal muscle

Identifiers

PMID41893350
PMCPMC13028232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.