Evidence map›Paper›PMID 41893311›Full record

ArticleMetabolites2026

Agata Serrafi, Małgorzata Pupek, Łukasz Lewandowski, Anna Janicka-Kłos, Andrzej Wasilewski, Adrian Kasprzak, Agnieszka Matera-Witkiewicz, Tomasz Zatoński, Katarzyna Połtyn-Zaradna, Milena Ściskalska and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Agata SerrafiDepartment of Chemistry and Immunochemistry, Wroclaw Medical University, ul. M. Sklodowskiej-Curie 48/50, 50-369 Wroclaw, Poland.ORCID 0000-0002-2826-6623
Małgorzata PupekDepartment of Chemistry and Immunochemistry, Wroclaw Medical University, ul. M. Sklodowskiej-Curie 48/50, 50-369 Wroclaw, Poland.
Łukasz LewandowskiDepartment of Medical Biochemistry, Wroclaw Medical University, ul. T. Chałubińskiego 10, 50-368 Wrocław, Poland.
Anna Janicka-KłosDepartment of Basic Chemistry, Wroclaw Medical University, ul. Borowska 211A, 50-556 Wroclaw, Poland.
Andrzej WasilewskiStudent Scientific Association of Medical Chemistry and Immunochemistry, Wroclaw Medical University, 50-369 Wroclaw, Poland.ORCID 0000-0001-9908-6921
Adrian KasprzakStudent Scientific Association of Medical Chemistry and Immunochemistry, Wroclaw Medical University, 50-369 Wroclaw, Poland.
Agnieszka Matera-WitkiewiczWroclaw Medical University Biobank, Screening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University, ul. Borowska 211A, 50-556 Wrocław, Poland.ORCID 0000-0002-1064-1237
Tomasz ZatońskiDepartment and Clinic of Otolaryngology, Head and Neck Surgery, Wrocław Medical University, Borowska 213, 50-556 Wrocław, Poland.ORCID 0000-0003-3043-4806
Katarzyna Połtyn-ZaradnaDepartment of Social Medicine, Wroclaw Medical University, 50-345 Wrocław, Poland.
Milena ŚciskalskaDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, Borowska 211a, 50-556 Wroclaw, Poland.ORCID 0000-0001-8976-6683
Tomasz BrutkowskiDepartment of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wrocław, Poland.
Bernarda KazanowskaDepartment of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wrocław, Poland.

Funding

National Science Centre MINI.A070.22.004
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis pilot study aimed to evaluate the metabolic profiles in plasma and cerebrospinal fluid (CSF) of 14 patients with acute lymphoblastic leukemia (ALL) and plasma of a control group, using proton magnetic resonance spectroscopy (

methodsMultivariate analysis, including orthogonal partial least-squares discriminant analysis (OPLS-DA), was used to analyze the metabolome composition.

resultsSignificant differences in plasma metabolic profiles were found between the ALL and control groups. We detected elevated levels of formate, citrate, and glycerophosphocholine (GPC), along with decreased concentrations of glutamine and

conclusionsOur findings suggest that metabolomic analysis with

Indexed as

acute lymphoblastic leukemiametabolomicsnuclear magnetic resonancepilot study

Identifiers

PMID41893311
PMCPMC13027993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.