Evidence map›Paper›PMID 41893192›Full record

ArticleJournal of functional biomaterials2026

Development of Freeze-Dried Hyaluronic Acid Sheets for Healing Oral Mucositis: Influence of Hyaluronic Acid Molecular Weight and Nicotinamide Mononucleotide Loading on Healing Efficacy.

Akiko Tanaka, Takanobu Takata, Hidemasa Katsumi, Yasuhisa Sawai, Hiroyuki Nakano, Chika Yoneto, Kunio Yoneto, Tomoyuki Furubayashi, Toshiyasu Sakane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akiko TanakaLaboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe 658-8558, Japan.
Takanobu TakataDivision of Molecular and Genetic Biology, Department of Life Science, Medical Research Institute, Kanazawa Medical University, Uchinada 920-0293, Japan.ORCID 0000-0003-0514-8584
Hidemasa KatsumiDepartment of Pharmaceutics, Graduate School of Pharmacy, Showa Medical University, Shinagawa-ku, Tokyo 142-8555, Japan.
Yasuhisa SawaiDepartment of Oral and Maxillofacial Surgery, Kanazawa Medical University, Uchinada 920-0293, Japan.ORCID 0009-0005-2428-3417
Hiroyuki NakanoDepartment of Oral and Maxillofacial Surgery, Kanazawa Medical University, Uchinada 920-0293, Japan.ORCID 0000-0002-0532-1853
Chika YonetoRitapharma, Co., Ltd., Shimogyo-ku, Kyoto 600-8813, Japan.
Kunio YonetoRitapharma, Co., Ltd., Shimogyo-ku, Kyoto 600-8813, Japan.
Tomoyuki FurubayashiLaboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe 658-8558, Japan.ORCID 0000-0002-4397-4353
Toshiyasu SakaneLaboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe 658-8558, Japan.

Funding

JSPS KAKENHI 24K14802OTC Self-Medication Promotion Foundation 48-2-20
6 · The paper itself

Abstract

Oral mucositis frequently develops during radiotherapy or chemotherapy for head and neck cancer and is characterized by severe pain and impaired eating and speech. It was previously demonstrated that freeze-dried hyaluronic acid (HA) sheets effectively promote the healing of oral mucosal ulcers. This study aimed to optimize the HA sheet formulation by evaluating the effects of HA molecular weight and nicotinamide mononucleotide (NMN) loading on therapeutic efficacy. HA sheets were prepared using HA with four different molecular weights (50, 350, 800, and 2000 kDa), and their therapeutic effects were evaluated in an animal oral ulcer model using 6-week-old male Syrian hamsters. Among the formulations tested, the 800 kDa HA sheet exhibited the greatest healing efficacy, and it showed an excellent balance between buccal retention and the sustained release of NMN for the treatment of oral mucositis. In vitro cytotoxicity assays confirmed that HA, with or without NMN, was non-toxic and suitable for local applications. These findings indicate that HA sheets, particularly those composed of 800 kDa HA, may represent a promising and biocompatible mucoadhesive material for the delivery of NMN and the local treatment of oral mucositis associated with head and neck cancer.

Indexed as

drug delivery systemhyaluronic acidnicotinamide mononucleotideoral mucositis

Identifiers

PMID41893192
PMCPMC13027328

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.