Evidence map›Paper›PMID 41893174›Full record

ArticleJournal of functional biomaterials2026

A Pre-Set Calcium Sulfate/Hydroxyapatite Biomaterial as an Antibiotic-Eluting Bone Extender and a Carrier for BMP-2: A Pilot Study in a Rabbit Posterolateral Spinal Fusion Model.

Jintian Huang, Gintarė Lukoševičiūtė, Filip Mrkonjic, Hadis Alidadi, Domantas Jakstas, Sujeesh Sebastian, Lars Lidgren, Magnus Tägil, Deepak Bushan Raina

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jintian HuangDepartment of Clinical Sciences Lund, Orthopedics, The Faculty of Medicine, Lund University, 22184 Lund, Sweden.ORCID 0009-0006-3599-3673
Gintarė LukoševičiūtėDepartment of Clinical Sciences Lund, Orthopedics, The Faculty of Medicine, Lund University, 22184 Lund, Sweden.ORCID 0009-0000-3573-634X
Filip MrkonjicDepartment of Clinical Sciences Lund, Orthopedics, The Faculty of Medicine, Lund University, 22184 Lund, Sweden.
Hadis AlidadiDepartment of Clinical Sciences Lund, Orthopedics, The Faculty of Medicine, Lund University, 22184 Lund, Sweden.
Domantas JakstasSpinal Neurosurgery Unit, Department of Neurosurgery, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Sujeesh SebastianMichael Ogon Laboratory for Orthopedic Research, Orthopedic Hospital Vienna-Speising, 1130 Vienna, Austria.ORCID 0000-0003-2575-4207
Lars LidgrenDepartment of Clinical Sciences Lund, Orthopedics, The Faculty of Medicine, Lund University, 22184 Lund, Sweden.
Magnus TägilDepartment of Clinical Sciences Lund, Orthopedics, The Faculty of Medicine, Lund University, 22184 Lund, Sweden.
Deepak Bushan RainaDepartment of Clinical Sciences Lund, Orthopedics, The Faculty of Medicine, Lund University, 22184 Lund, Sweden.ORCID 0000-0001-8767-892X

Funding

Consul Thure Carlsson Foundation 2025-DR2Olav Thon Foundation 2021-LLThe Kockska Foundation 2025-DR1
6 · The paper itself

Abstract

Synthetic biomaterials used as bone graft extenders (BGE) in spinal fusion surgery can supplement but do not replace autologous bone. This pilot study evaluated a calcium sulfate/hydroxyapatite (CaS/HA) material as an antibiotic-eluting BGE and a carrier for bone morphogenetic protein-2 (BMP-2) in a rabbit posterolateral lumbar (L4-L5) spinal fusion model (PLF). Pre-set CaS/HA beads were loaded with tobramycin (TOB) and tested for in vitro antibiotic release and antibacterial activity against

Indexed as

BMP-2bone graft extenderceramic materialinfectionspinal fusion

Identifiers

PMID41893174
PMCPMC13028491

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.