Evidence map›Paper›PMID 41893167›Full record

ArticleJournal of functional biomaterials2026

Influence of Micro-Nanostructured Anatase-Coated SLA Titanium on Macrophage Behavior.

Leila Mohammadnejad, Madeline Mangold, Hannah Conrady, Wafa Zafira, Evi Kimmerle-Mueller, Peter Schneider, Barbara Illing, Christiane von Ohle, Annika Hechler, Frank Rupp and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leila MohammadnejadDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Madeline MangoldDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Hannah ConradyDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Wafa ZafiraDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Evi Kimmerle-MuellerDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Peter SchneiderDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.ORCID 0009-0001-4353-9861
Barbara IllingDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Christiane von OhleDepartment of Conservative Dentistry and Periodontology, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Annika HechlerDepartment of Conservative Dentistry and Periodontology, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Frank RuppDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.
Stefanie KrajewskiDepartment of Medical Materials Science & Technology, Institute of Biomedical Engineering, University Hospital Tübingen, Osianderstr. 2-8, 72076 Tübingen, Germany.

Funding

Medentis GmbH n/a
6 · The paper itself

Abstract

The success of titanium dental implants rely on osseointegration, influenced by surface properties and early immune responses. While sandblasted and acid-etched (SLA) titanium surfaces have shown clinical success, macrophage-mediated immune responses at these interfaces remain poorly understood. Anatase nanostructures have been shown to influence macrophage polarization on smooth titanium, but their effects on micro-rough SLA surfaces are not fully explored. This study investigates the immunomodulatory effects of micro-nanostructured anatase coatings on SLA titanium using human monocyte-derived macrophages (MDMs). M0-MDMs, were cultured and polarized to M1 and M2- macrophages on Ti-machined, Ti-SLA, Ti-SLA-anatase, and coverslip control surfaces for 48 h. Macrophage behavior was assessed using CCK-8 assay, confocal microscopy, SEM, ELISA, and qRT-PCR. All surfaces demonstrated excellent cytocompatibility, with similar macrophage viability across all investigated groups. M1 macrophages showed upregulation of CCR7 and TNF-α, while M2 macrophages expressed CD209 and CCL13 across all surfaces. Importantly, Ti-SLA-anatase did not significantly alter M1 or M2 markers, cytokine secretion, or gene expression, and did not exacerbate inflammatory responses. Micro-nanostructured anatase coatings on SLA titanium are immunologically well-tolerated and do not increase inflammation. These findings, combined with previously reported enhanced osteogenic properties, suggest the clinical potential of anatase-coated SLA surfaces.

Indexed as

anatasedental implantshuman monocyte-derived macrophagesimmunomodulation

Identifiers

PMID41893167
PMCPMC13026796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.