ArticleMarine drugs2026
Screening and Evaluation of Chassis Cells for Heterologous Biosynthesis of Gas Vesicles as Ultrasound Contrast Agents.
Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gas vesicles (GVs) are hollow protein nanostructures derived from microorganisms and show significant potential for ultrasound imaging applications. However, the direct production of gas vesicles (GVs) from their native hosts faces several limitations: poor contrast imaging performance, insufficient yield, and high costs associated with extraction and purification. These challenges heavily hinder their clinical translation and application. The heterologous expression of GV genes varies significantly among different chassis strains due to their distinct intracellular environments, which ultimately affects GV performance and yield. Therefore, it is crucial to select an appropriate chassis cell that can produce GVs with excellent imaging performance. In this study, the GV gene cluster from
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