Evidence map›Paper›PMID 41892952›Full record

ReviewMarine drugs2026

Bioactive Secondary Metabolites at the Ends of the Earth (2015-2025): Insights into Arctic and Antarctic Aquatic Sources.

Kim-Hoa Phi, Eun Jin Heo, Sunbeom Kwon, Ui Joung Youn, Seulah Lee

Abstract readReview
In one paragraph

Review in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kim-Hoa PhiDivision of Life Sciences, Korea Polar Research Institute, Incheon 21990, Republic of Korea.ORCID 0000-0002-5109-7813
Eun Jin HeoBK21 Interdisciplinary Program in IT-Bio Convergence System, Department of Convergent Biotechnology and Advanced Materials Science, Kyung Hee University, Yongin 17104, Republic of Korea.
Sunbeom KwonBK21 Interdisciplinary Program in IT-Bio Convergence System, Department of Convergent Biotechnology and Advanced Materials Science, Kyung Hee University, Yongin 17104, Republic of Korea.
Ui Joung YounDivision of Life Sciences, Korea Polar Research Institute, Incheon 21990, Republic of Korea.ORCID 0000-0001-9338-7934
Seulah LeeBK21 Interdisciplinary Program in IT-Bio Convergence System, Department of Convergent Biotechnology and Advanced Materials Science, Kyung Hee University, Yongin 17104, Republic of Korea.

Funding

National Research Foundation of Korea RS-2023-00212670National Research Foundation of Korea RS-2024-00358682National Research Foundation of Korea RS-2025-25442355
6 · The paper itself

Abstract

Marine organisms living in extreme environments such as the Arctic and Antarctic have evolved remarkable adaptation mechanisms to survive harsh conditions, including low temperatures, high salinity, and seasonal fluctuations in light and nutrients. Among these adaptations, unique biochemical pathways have given rise to secondary metabolites with unprecedented chemical structures and diverse biological activities. This review focuses on bioactive natural products that have been isolated from polar aquatic organisms between 2015 and 2025. It provides a comprehensive overview of these compounds, highlighting their chemical structures, source organisms, and documented biological activities. By examining recent discoveries from the ends of the Earth, this review underscores the rich chemical diversity of polar marine ecosystems and their continued potential as a source of novel molecules for drug discovery and biotechnology.

Indexed as

Aquatic OrganismsBiological ProductsAnimalsAntarctic RegionsArctic RegionsDrug DiscoveryEcosystemHumansBiological ProductsAntarcticaaquatic sourcesArcticbioactive compoundssecondary metabolites

Identifiers

PMID41892952
PMCPMC13028093

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.