Lensless Quantitative Phase Imaging with Bayer-Filtered Color Sensors Under Sequential RGB-LED Illumination.

Jiajia Wu, Yining Li, Yuheng Luo, Leiting Pan, Pengming Song, Qiang Xu

Abstract read

In one paragraph

Article in Journal of imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jiajia WuSchool of Physics, TEDA Institute of Applied Physics, Nankai University, Tianjin 300071, China.

Yining LiGuangzhou National Laboratory, Guangzhou International BioIsland, Guangzhou 510005, China.

Yuheng LuoGuangzhou National Laboratory, Guangzhou International BioIsland, Guangzhou 510005, China.

Leiting PanSchool of Physics, TEDA Institute of Applied Physics, Nankai University, Tianjin 300071, China.

Pengming SongGuangzhou National Laboratory, Guangzhou International BioIsland, Guangzhou 510005, China.

Qiang XuGuangzhou National Laboratory, Guangzhou International BioIsland, Guangzhou 510005, China.

Funding

Guangzhou National Laboratory No. GZNL2024A01029National Natural Science Foundation of China No. 62505056

6 · The paper itself

Abstract

Lensless on-chip microscopy enables high-throughput, wide-FOV imaging; however, the Bayer color filter array (CFA) in standard color sensors spatially multiplexes spectral channels, introducing sub-sampling and spectral crosstalk that degrade phase retrieval. We propose a Wirtinger Poly-Gradient Solver (WPGS) for quantitative phase reconstruction with Bayer-filtered color sensors under sequential Red-Green-Blue Light-Emitting Diode (RGB-LED) illumination. The method combines Transport of Intensity Equation (TIE)-based initialization with polychromatic Wirtinger optimization to suppress CFA-induced artifacts and enable pixel super-resolution (PSR). Experiments resolve a 2.76 μm linewidth using a 1.85 μm pixel-pitch sensor, exceeding the nominal Nyquist limit imposed by pixel sampling. We further demonstrate label-free imaging of HeLa cells and unstained tissue sections, supporting high-throughput digital pathology and offering potential for longitudinal biological observation.

Indexed as

Bayer-filtered color sensorlensless on-chip microscopypolychromatic phase retrievalquantitative phase imaging

Identifiers

PMID41892903

DOI10.3390/jimaging12030101

PMCPMC13028210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.