ArticleMedical sciences (Basel, Switzerland)2026
Clinical Evolution of a Cohort of Patients with COVID-19 Treated with Usual Medical Care Plus Polymerized Type I Collagen During the Pandemic Emergency.
Article in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe COVID-19 pandemic created an urgent need for safe and accessible outpatient treatments. Polymerized type I collagen (PTIC) has demonstrated potential immunomodulatory effects, but its clinical utility in patients with COVID-19 remains underexplored. This study aimed to evaluate the clinical evolution and health outcomes of a cohort of patients with COVID-19 treated with standard medical care plus PTIC during the pandemic emergency, in order to explore its potential role as an adjuvant therapy.
methodsA retrospective cohort study was conducted in 46 outpatients with confirmed COVID-19 treated with PTIC (Fibroquel
resultsOxygen saturation levels increased significantly from 88.5 ± 5.22 to 95.1 ± 2.07 after PTIC treatment. Supplemental oxygen was required for 26.1% of patients receiving treatment, compared to 60% of those in the untreated group (
conclusionsPTIC significantly improved clinical parameters in patients with COVID-19. It improves oxygen saturation levels, decreases the need for supplemental oxygen, and improves survival compared to patients who are not treated with PTIC. Additional studies are needed to validate the use of PTIC as an adjunctive therapy for patients with COVID-19.
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