Alpha-1 Antitrypsin Deficiency Beyond COPD and Emphysema: A Narrative Review.

Lucia Pastoressa, Vanessa Pivetti, Marialuisa Valente, Bianca Beghè, Enrico Clini, Roberto Tonelli, Stefania Cerri

Abstract readReview

In one paragraph

Review in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucia PastoressaDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Vanessa PivettiDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0009-0007-8768-065X

Marialuisa ValenteDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Bianca BeghèDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Enrico CliniDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0002-1515-5094

Roberto TonelliDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Stefania CerriDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0003-4612-1580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha 1-Antitrypsin DeficiencyAsthmaEmphysemaPulmonary Disease, Chronic ObstructivePulmonary Emphysemaalpha 1-AntitrypsinBronchiectasisHumansLeukocyte Elastasealpha 1-AntitrypsinLeukocyte Elastasealpha-1 antitrypsinasthmabronchiectasischronic obstructive pulmonary diseaseemphysemaneutrophil elastaseprotease–antiprotease imbalance

Identifiers

PMID41892821

DOI10.3390/medsci14010106

PMCPMC13028115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.