Effect Modification by Acute Coronary Syndrome Prevalence on Non-Invasive Ventilation Efficacy in Acute Cardiogenic Pulmonary Edema: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Marek Tomala, Monika Durak, Magdalena Borówka, Paweł Szkarłat, Maciej Kłaczyński

Abstract readReview

In one paragraph

Review in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marek TomalaCenter for Invasive Cardiology, Electrotherapy, and Angiology, Clinical Research Center Intercard, 30-505 Krakow, Poland.ORCID 0000-0001-7882-9255

Monika DurakCenter for Invasive Cardiology, Electrotherapy, and Angiology, Clinical Research Center Intercard, 30-505 Krakow, Poland.

Magdalena BorówkaPediatric Intensive Care Unit, Department of Women, Child and Adolescent Medicine, Geneva University Hospital, 1205 Geneva, Switzerland.

Paweł SzkarłatCenter for Invasive Cardiology, Electrotherapy, and Angiology, Clinical Research Center Intercard, 30-505 Krakow, Poland.ORCID 0009-0002-6897-4349

Maciej KłaczyńskiDepartment of Mechanics and Vibroacoustics, Faculty of Mechanical Engineering and Robotics, AGH University of Science and Technology, 30-059 Krakow, Poland.ORCID 0000-0002-2009-1216

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive ventilation (NIV) reduces mortality in patients with acute cardiogenic pulmonary edema (ACPE). However, the 3CPO trial reported null results. Therefore, we hypothesized that the prevalence of acute coronary syndrome (ACS) would influence the effectiveness of NIV. A systematic literature review was conducted to identify randomized controlled trials (RCTs) comparing NIV and standard oxygen therapy in patients with ACPE from PubMed, CENTRAL, and Embase databases through December 2025. Random-effects meta-analysis and REML meta-regression were utilized, and evidence quality was evaluated using GRADE. (PROSPERO: CRD420251142245). Fourteen RCTs (

Indexed as

acute cardiogenic pulmonary edemaacute coronary syndromeBiPAPCPAPeffect modificationmeta-analysismeta-regressionmyocardial infarctionnoninvasive ventilation

Identifiers

PMID41892723

DOI10.3390/jcdd13030135

PMCPMC13026454

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.