Prognostic Value of Cadmium-Zinc-Telluride Dedicated Cardiac SPECT Dynamic Myocardial Perfusion Quantitative Imaging in Patients with Coronary Chronic Total Occlusion: A Pilot Study.

Linlin Li, Zekun Pang, Jianming Li, Wengui Xu

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Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Linlin LiDepartment of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China.

Zekun PangDepartment of Nuclear Medicine, TEDA International Cardiovascular Hospital, No. 61, 3rd Street, Binhai New Area, Tianjin 300457, China.

Jianming LiDepartment of Nuclear Medicine, TEDA International Cardiovascular Hospital, No. 61, 3rd Street, Binhai New Area, Tianjin 300457, China.ORCID 0000-0002-2585-4753

Wengui XuDepartment of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China.

Funding

Tianjin Key Medical Discipline (Specialty) Construction Project, Tianjin, China TJYXZDXK-010A

6 · The paper itself

Abstract

backgroundThe prevalence of chronic total occlusion (CTO) lesions is as high as 30% in patients undergoing coronary angiography (CAG). Some CTO patients do not undergo revascularization due to procedural complexity and high risks. This study aimed to investigate the value of cadmium-zinc-telluride (CZT) SPECT dynamic myocardial perfusion imaging (MPI) for risk stratification and prognosis assessment in patients with coronary CTO.

methodsThis study retrospectively included 62 patients who underwent CZT SPECT dynamic MPI examination and were diagnosed with CTO by angiography. The primary endpoint was major adverse cardiovascular events (MACEs), defined as cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, hospitalization for heart failure, late coronary revascularization, or hospitalization for unstable angina.

resultsOver a median follow-up of 17 months (IQR 11-23), 15 MACEs occurred. The stress myocardial blood flow (sMBF) and coronary flow reserve (CFR) in the CTO territory were significantly lower in the MACEs group compared to the non-MACEs group (all

conclusionsThe results of this study indicate that sMBF and CFR obtained from CZT SPECT dynamic MPI provide valuable prognostic prediction for patients with coronary CTO lesions, offering critical evidence for identifying high-risk patients requiring active intervention.

Indexed as

cadmium-zinc-telluridechronic total occlusionmyocardial blood flow quantificationprognostic valuerisk stratification

Identifiers

PMID41892707

DOI10.3390/jcdd13030118

PMCPMC13027361

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