Evidence map›Paper›PMID 41892624›Full record

ArticleBrain sciences2026

Study Protocol of a Pilot Trial Evaluating the Efficacy of an Integrated Therapeutic Intervention Based on Role-Playing Games (RPGs) in Adolescents and Young Adults with Anxiety, Depression and Emotional Dysregulation Disorders.

Cristiano Lupi, Laura Orsolini, Alberto Conte, Giuseppe Loris Nuzzo, Umberto Volpe

Abstract read
In one paragraph

Article in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cristiano LupiUnit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, 60126 Ancona, Italy.
Laura OrsoliniUnit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0002-6882-3770
Alberto ConteUnit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, 60126 Ancona, Italy.
Giuseppe Loris NuzzoUnit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, 60126 Ancona, Italy.
Umberto VolpeUnit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0001-9166-7609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adolescence and early adulthood are critical developmental periods marked by an increasing vulnerability to emotional dysregulation and social difficulties, highlighting the need for engaging psychosocial interventions. This protocol presents a pilot study on the efficacy, feasibility, and acceptability of a structured group intervention based on Role-Playing Games (RPGs), designed to promote and support psychological well-being in transitional-aged youths. The study plans to recruit 54 participants (aged 15-24) who will take part in a 12 weekly, 2 h RPG-based intervention facilitated by trained clinicians. These clinicians will guide patients through narrative role-playing and a guided mentalization-based therapy through the gaming experience. All participants will be assessed at pre-, mid- and post-intervention, as well as during the 1- and 6-month follow-up, in the following dimensions: (a) mood, (b) anxiety, (c) emotional regulation, (d) alexithymia, and (e) coping skills. The following assessment tools will be administered: Hospital Anxiety and Depression Scale (HADS), Difficulties in Emotion Regulation Scale (DERS), Toronto Alexithymia Scale (TAS-20), and Coping Orientation to Problems Experienced (Brief-COPE). We expect the trial pilot will demonstrate good feasibility, greater participant engagement and treatment adherence, and improvements in all emotional and affective dimensions. This study seeks to establish foundational data to inform larger randomized controlled trials, with a follow-up, positioning RPG-based group interventions as potentially accessible, engaging, and convenient tools within youth mental health services.

Indexed as

adolescent mental healthemotional regulationgamingRole-Playing Games (RPGs)youth anxietyyouth depression

Identifiers

PMID41892624
PMCPMC13023783

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.