Solvent Removal Salicylic Acid-Loaded Myristic Acid-Based In Situ Forming Gel.

Kritamorn Jitrangsri, Napaphol Puyathorn, Sai Myo Thu Rein, Jitnapa Sirirak, Parichat Chomto, Thawatchai Phaechamud

Abstract read

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Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Kritamorn JitrangsriDepartment of Industrial Pharmacy, School of Pharmacy, Walailak University, Nakhon Srithammarat 80160, Thailand.

Napaphol PuyathornDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0001-7794-5764

Sai Myo Thu ReinDepartment of Pharmacognosy, University of Pharmacy, Mandalay 05012, Myanmar.

Jitnapa SirirakDepartment of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand.ORCID 0000-0002-5818-4581

Parichat ChomtoDivision of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.

Thawatchai PhaechamudDivision of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.ORCID 0000-0003-2270-5303

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to develop a solvent removal-based in situ forming gel (ISG) loaded with salicylic acid (SAL) using myristic acid (MYR) as a matrix-forming agent. SAL-loaded MYR-based ISGs were prepared using N-methyl-2-pyrrolidone (NMP) or dimethyl sulfoxide (DMSO) as solvents and evaluated for physicochemical properties, matrix formation behavior, mechanical characteristics, and in vitro drug release. Increasing MYR content influenced viscosity, gel formation kinetics, and depot integrity, resulting in prolonged SAL release of up to 20 days in DMSO-based formulations. The release kinetics were best described by the Peppas-Sahlin model, indicating diffusion-dominated drug transport. The selected formulation containing 30%

Indexed as

in situ forming gelmyristic acidsalicylic acidsolvent removal

Identifiers

PMID41892541

DOI10.3390/gels12030220

PMCPMC13025416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.