Evidence map›Paper›PMID 41892490›Full record

ArticleClinics and practice2026

Psoriasis in Difficult-to-Treat Areas: A Multicentre, Real-World Retrospective Study Analyzing the Impact of Non-Invasive Imaging Techniques (Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography) to Monitor the Effectiveness of Risankizumab in the Treatment of Plaque Psoriasis of the Legs.

Annunziata Dattola, Raimondo Rossi, Giuseppe Rizzuto, Giacomo Caldarola, Eleonora De Luca, Viviana Lora, Domenico Giordano, Severino Persechino, Claudio Bonifati, Diego Orsini and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Annunziata DattolaDermatology Unit, Department of Medical and Cardiovascular Sciences, University of "La Sapienza", 00161 Rome, Italy.ORCID 0000-0001-9504-5882
Raimondo RossiDermatology Unit, Department of Medical and Cardiovascular Sciences, University of "La Sapienza", 00161 Rome, Italy.
Giuseppe RizzutoDermatology Unit, Department of Medical and Cardiovascular Sciences, University of "La Sapienza", 00161 Rome, Italy.ORCID 0009-0001-4367-0341
Giacomo CaldarolaUnità Operativa Complessa di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli-IRCCS, 00168 Rome, Italy.ORCID 0000-0002-8837-9232
Eleonora De LucaUnità Operativa Complessa di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli-IRCCS, 00168 Rome, Italy.
Viviana LoraClinical Dermatology Unit, San Gallicano Dermatological Institute (IRCCS), 00144 Rome, Italy.
Domenico GiordanoDermatology Unit, NESMOS Departement, Sant'Andrea Hospital, University of Rome Sapienza, 00189 Rome, Italy.
Severino PersechinoDermatology Unit, NESMOS Departement, Sant'Andrea Hospital, University of Rome Sapienza, 00189 Rome, Italy.
Claudio BonifatiClinical Dermatology Unit, San Gallicano Dermatological Institute (IRCCS), 00144 Rome, Italy.
Diego OrsiniDepartmental Faculty of Medicine, UniCamillus-"Saint Camillus International University of Health and Medical Sciences", 00131 Rome, Italy.
Dario GraceffaClinical Dermatology Unit, San Gallicano Dermatological Institute (IRCCS), 00144 Rome, Italy.
Arianna ZangrilliUnità Operativa Semplice Dipartimentale di Dermatologia, Dipartimento di Scienze Mediche, Azienda Ospedaliera Universitaria Policlinico Tor Vergata, 00133 Rome, Italy.
Gianluca PagnanelliDepartment of Dermatology, IDI-IRCCS, 00167 Roma, Italy.
Paola TribuziUnità Operativa Semplice Dipartimentale Ospedale Belcolle ASL Viterbo, 01100 Viterbo, Italy.
Annamaria MazzottaAzienda OspedalieraSan Camillo Forlanini of Rome Cir.ne Gianicolense, 00152 Rome, Italy.
Gaia MorettaDepartment of Dermatology, IDI-IRCCS, 00167 Roma, Italy.ORCID 0000-0002-8839-5961
Adriana MicheliUnità di Dermatologia, Ospedale Nuovo Regina Margherita, 00153 Rome, Italy.
Alessia ProviniAzienda Sanitaria Locale Roma 2, Ospedale S. Pertini, 00157 Rome, Italy.
Salvatore ZanframundoDepartment of Medicine and Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Vincenzo PanasitiDepartment of Medicine and Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Giovanni PellacaniDermatology Unit, Department of Medical and Cardiovascular Sciences, University of "La Sapienza", 00161 Rome, Italy.ORCID 0000-0002-7222-2951
Concetta PotenzaDermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Biotechnologies, La Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy.
Antonio Giovanni RichettaDermatology Unit, Department of Medical and Cardiovascular Sciences, University of "La Sapienza", 00161 Rome, Italy.ORCID 0000-0002-8755-9178
Nicoletta BernardiniDermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Biotechnologies, La Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy.ORCID 0000-0002-6295-3574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the impact of non-invasive imaging techniques such as dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) to monitor the efficacy of risankizumab on plaque psoriasis of the legs by analyzing morpho-histological changes. MATERIALS AND

methodsMulticentre, real-world retrospective study involving 37 adults with moderate-to-severe plaque psoriasis. Assessments performed during routine visits at baseline, Week 4 and Week 12 included clinical response, dermoscopy, RCM and OCT.

resultsThirty-seven patients were included (mean age 52.1 years; 54% male; mean BMI 27.0 kg/m

conclusionsRisankizumab induced rapid, significant regression of psoriatic changes, normalizing vascular patterns and skin architecture and reducing epidermal thickness. Findings support its efficacy and rapid onset of action in difficult-to-treat areas and highlight the value of non-invasive imaging for monitoring.

Indexed as

dermoscopydifficult-to-treat areasoptical coherence tomographypsoriasisreflectance confocal microscopyrisankizumab

Identifiers

PMID41892490
PMCPMC13025591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.