ArticleActa crystallographica. Section D, Structural biology2026
ICECREAM: high-fidelity equivariant cryo-electron tomography.
Article in Acta crystallographica. Section D, Structural biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome.Nature plants · 2026Article
- Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome.bioRxiv : the preprint server for biology · 2026Article
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5 authors.
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Abstract
Cryo-electron tomography (cryo-ET) visualizes 3D cellular architecture in its near-native state. The various deep-learning methods have improved denoising and artifact correction, but remain challenged by a very low signal-to-noise ratio, a restricted tilt range (`missing wedge') and the lack of ground truth. Here, we present ICECREAM, which bridges earlier self-supervised methods with the recent equivariant imaging framework [Chen et al. (2021), IEEE/CVF International Conference on Computer Vision (ICCV), pp. 4359-4368]. Across diverse experimental datasets, ICECREAM achieves substantially better denoising and more reliable missing-wedge filling than existing methods. ICECREAM can be applied to any tomography problem that provides two statistically independent views of the volume; in cryo-ET these are obtained by dose splitting or angular partitioning of the tilt series. ICECREAM is openly available at https://github.com/swing-research/icecream.
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