ArticleAntibiotics (Basel, Switzerland)2026
Multicenter Analytical Performance Evaluation of the BD Phoenix NMIC-461 Panel for Carbapenemase Classification and Antimicrobial Susceptibility Testing of
Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
methodsA total of 714 non-repetitive clinical isolates from three tertiary hospitals in China were enrolled. Carbapenemase production was confirmed by the modified carbapenem inactivation method (mCIM), while carbapenemase typing was validated by polymerase chain reaction (PCR) and Sanger sequencing. Antimicrobial susceptibility testing (AST) for ten antimicrobial agents was performed using broth microdilution (BMD) as the reference method.
resultsThe sensitivity and specificity of carbapenemase detection were 98.8% (95% CI, 96.6-99.6) and 92.4% (95% CI, 89.5-94.6) separately compared to sequencing. Classification accuracy was compromised by carbapenemase-positive unclassified strains, particularly reducing sensitivity for
conclusionsThe BD Phoenix NMIC-461 panel provides reliable AST results for commonly encountered Gram-negative bacterial isolates. Regarding carbapenemase detection, the panel demonstrates high sensitivity but only moderate specificity in classifying carbapenemase-producing organisms (CPO), with a relatively high proportion of positive unclassified isolates among
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