Inflammation-Driven Downregulation of CYP2E1 Is Associated with Attenuated Diethylnitrosamine (DEN)-Induced Hepatocarcinogenesis.

Yoshihiro Tsuchiya, Yusuke Sotomaru, Akinori Kanai, Shin Maeda, Hideaki Kamata

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yoshihiro TsuchiyaDepartment of Nutrition and Health, Faculty of Human Life Studies, Hiroshima Jogakuin University, Hiroshima 732-0063, Japan.

Yusuke SotomaruNatural Science Center for Basic Research and Development, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.ORCID 0000-0002-2856-1518

Akinori KanaiGraduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562, Japan.

Shin MaedaDepartment of Gastroenterology, School of Medicine, Yokohama City University, Yokohama 236-0004, Japan.ORCID 0000-0002-0246-1594

Hideaki KamataDepartment of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima 734-8553, Japan.

Funding

Japan Society for the Promotion of Science JP25840035, JP16K18419, and JP19K07642

6 · The paper itself

Abstract

Inflammation is widely viewed as a driver of hepatocellular carcinoma (HCC), yet inflammatory signaling also reshapes hepatic xenobiotic metabolism. Here, we established transgenic (Tg) IKKβ

Indexed as

CarcinogenesisCarcinoma, HepatocellularCytochrome P-450 CYP2E1Down-RegulationInflammationLiver NeoplasmsAnimalsDiethylnitrosamineDNA DamageHepatocyte Nuclear Factor 4I-kappa B KinaseMiceMice, TransgenicXenobioticsCytochrome P-450 CYP2E1DiethylnitrosamineHepatocyte Nuclear Factor 4I-kappa B KinaseXenobioticsCYP2E1diethylnitrosaminehepatic xenobiotic metabolismhepatocellular carcinomaIKKβ/NF-κB

Identifiers

PMID41892336

DOI10.3390/cells15060546

PMCPMC13025445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.