Evidence map›Paper›PMID 41892334›Full record

ArticleCells2026

Harnessing Gut Endocrine Cell Plasticity to Restore Insulin Production.

Chaïma Ayachi, Tiziana Napolitano, Serena Silvano, Sophie Giorgetti-Peraldi, Ahmed Mansouri, Raphaël Rapetti-Mauss, Hugo Fofo, Valentin Lepage, Laura Etasse, Caroline Treins and 2 more

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chaïma AyachiFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Tiziana NapolitanoFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Serena SilvanoFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Sophie Giorgetti-PeraldiFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Ahmed MansouriDepartment of Clinical Neurophysiology, University of Göttingen, 37075 Goettingen, Germany.
Raphaël Rapetti-MaussFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Hugo FofoFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Valentin LepageFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Laura EtasseFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Caroline TreinsFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Loan TranFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.
Patrick CollombatFaculté des Sciences, Université Côte d'Azur, 06100 Nice, France.ORCID 0000-0001-8232-1438

Funding

Agence Nationale pour la Recherche ANR-16-CE18-0005-01Agence Nationale pour la Recherche ANR-17-CE14-0034IDEX UCA Jedi ANR-15-IDEX-01Juvenile Diabetes Research Foundation 2-SRA-2017-416-S-BJuvenile Diabetes Research Foundation 2-SRA-2017-417-S-BLABEX SIGNALIFE ANR-11-LABX-0028-01
6 · The paper itself

Abstract

Type 1 diabetes (T1D) results from autoimmune-mediated destruction of pancreatic β-cells, leading to insulin deficiency and chronic hyperglycemia. β-cell replacement represents a promising therapeutic strategy, yet the identification of a sustainable and immune-compatible cell source remains a major challenge. Here, we explore the potential of the gastrointestinal (GI) epithelium as an alternative source of β-cells through in vivo cellular reprogramming. Given the large size and highly regenerative nature of the GI tract, partial reprogramming could provide a renewable source of insulin-producing (insulin

Indexed as

Cell PlasticityEndocrine CellsGastrointestinal TractInsulinInsulin-Secreting CellsAnimalsCell DifferentiationCellular ReprogrammingGlucoseHomeodomain ProteinsHumansMiceOrganoidsPaired Box Transcription FactorsGlucoseHomeodomain ProteinsInsulinPaired Box Transcription FactorsPax4 protein, mousecellular reprogramminggastrointestinal tractL-cellsPax4type 1 diabetesβ-cell regeneration

Identifiers

PMID41892334
PMCPMC13026060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.