Evidence map›Paper›PMID 41892324›Full record

ArticleCells2026

TRPC6-Mediated Ca

Janitri Venkatachala Babu, Varun Puvanesarajah, Addisu Mesfin, Jonathan P Japa, Kevin Yoon, Mark Ehioghae, Michael G Schrlau, Laura S Stone, Wolfgang Hitzl, Karin Wuertz-Kozak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Janitri Venkatachala BabuDepartment of Biomedical Engineering, Rochester Institute of Technology (RIT), Rochester, NY 14623, USA.
Varun PuvanesarajahDepartment of Orthopaedics and Physical Performance, University of Rochester Medical Center, Rochester, NY 14642, USA.
Addisu MesfinMedStar Orthopaedic Institute, MedStar Georgetown University Hospital, Washington, DC 20010, USA.
Jonathan P JapaMedStar Orthopaedic Institute, MedStar Georgetown University Hospital, Washington, DC 20010, USA.ORCID 0009-0007-8723-7682
Kevin YoonMedStar Orthopaedic Institute, MedStar Georgetown University Hospital, Washington, DC 20010, USA.
Mark EhioghaeMedStar Orthopaedic Institute, MedStar Georgetown University Hospital, Washington, DC 20010, USA.
Michael G SchrlauDepartment of Mechanical Engineering, Rochester Institute of Technology (RIT), Rochester, NY 14623, USA.
Laura S StoneDepartment of Anesthesiology, Faculty of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-7015-2101
Wolfgang HitzlDepartment of Ophthalmology and Optometry, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0000-0002-7696-1479
Karin Wuertz-KozakDepartment of Biomedical Engineering, Rochester Institute of Technology (RIT), Rochester, NY 14623, USA.ORCID 0000-0002-3281-4629

Funding

Eurospine, The Spine Society of Europe 2023-027
6 · The paper itself

Abstract

Intervertebral disc degeneration is characterized by inflammation, extracellular matrix breakdown, and neurovascular ingrowth, processes that contribute to discogenic, chronic back pain. The transient receptor potential canonical 6 (TRPC6) channel is a calcium-permeable ion channel implicated in inflammation and pain signaling in multiple tissues; however, its functional role in human disc cells remain unknown. Here, we investigated the expression, activation, and downstream consequences of TRPC6 activation using Hyp9, a pharmacological activator of TRPC6.

Indexed as

CalciumInflammationIntervertebral DiscMitogen-Activated Protein KinasesNF-kappa BTRPC6 Cation ChannelHumansPhosphorylationSignal TransductionCalciumMitogen-Activated Protein KinasesNF-kappa BTRPC6 Cation ChannelTRPC6 protein, humancalcium-dependent pathwayscytokine regulationdegenerative disc diseasediscogenic back painHyp9ion channelMMPsneurovascular ingrowthtransient receptor potential channels (TRP channels)

Identifiers

PMID41892324
PMCPMC13025513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.