Evidence map›Paper›PMID 41892283›Full record

ArticleCells2026

BMPR2 Dosage Gates BMP9/10 Signaling Output in Pulmonary Artery Endothelium.

Kit-Yee Chu, Vijayalakshmi Thamilselvan, Amberly N Crawford, Paul B Yu, Erik Martinez-Hackert

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kit-Yee ChuDepartment of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.ORCID 0000-0001-7638-0191
Vijayalakshmi ThamilselvanDepartment of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.
Amberly N CrawfordDepartment of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.
Paul B YuCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Erik Martinez-HackertDepartment of Biochemistry and Molecular Biology, Michigan State University, 603 Wilson Road, East Lansing, MI 48824, USA.

Funding

Context-specific angiogenic signaling in the pulmonary vasculatureR01HL159443 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI YU, PAUL B · 2021 to 2024
$2.4M
TGF-β signaling and regulation: Elucidating molecular mechanisms and pathogenic functions of the ‘co-receptor’ Cripto-1 and the receptor BMPRIIR01GM121499 · NIGMS · MICHIGAN STATE UNIVERSITY · PI MARTINEZ HACKERT, ERIK MATTHIAS · 2018 to 2022
$1.5M
NHLBI NIH HHS R01 HL159443NHLBI NIH HHS R01HL159443NIGMS NIH HHS R01GM121499
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is characterized by dysfunction and remodeling of the pulmonary artery endothelium and smooth muscle. In heritable PAH, heterozygous loss-of-function mutations in the type II Bone Morphogenetic Protein (BMP) receptor gene (

Indexed as

Bone Morphogenetic Protein Receptors, Type IIBone Morphogenetic ProteinsEndothelium, VascularGrowth Differentiation Factor 2Growth Differentiation FactorsPulmonary ArterySignal TransductionCell ProliferationEndothelial CellsHumansBMP10 protein, humanBMPR2 protein, humanBone Morphogenetic Protein Receptors, Type IIBone Morphogenetic ProteinsGDF2 protein, humanGrowth Differentiation Factor 2Growth Differentiation FactorsACVR2AbimagrumabBMP9/BMP10BMPR2endothelial dysfunctionpulmonary arterial hypertensionsignal transduction

Identifiers

PMID41892283
PMCPMC13025488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.