ATF4 Is Dispensable for Spermatogenesis but Protective Against ER Stress Under Normal Conditions.

Mingxing Zhang, Zhicheng Wu, Yilan Teng, Hongwen Zhu, Peng Dai

Abstract read

In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mingxing ZhangShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.ORCID 0009-0000-1244-6278

Zhicheng WuShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

Yilan TengShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

Hongwen ZhuPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou 510006, China.ORCID 0000-0002-2116-4245

Peng DaiShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.ORCID 0009-0001-0915-3033

Funding

he National Key R&D Program of China 2022YFA1305300National Natural Science Foundation of China 32171287, 82573946 and 32301235Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai, Shanghai Rising-Star Pro-gram 21QA1409400Science and Technology Commission of Shanghai Municipality 228001437The APC was funded by the National Key R&D Program of China 2022YFA1305300the Fundamental Research Funds for the Central Universities 22120240435

6 · The paper itself

Abstract

Spermatogenesis is a metabolically intensive process that is highly sensitive to perturbations in proteostasis. The integrated stress response (ISR) and its central effector, ATF4, orchestrate adaptive responses to maintain cellular homeostasis under stress; however, the functional significance of ATF4 in mammalian spermatogenesis has not been established. To investigate this, we engineered a conditional knockout mouse model with germ cell-specific deletion of the

Indexed as

Atf4ER stressintegrated stress responsemale fertilityspermatogenesis

Identifiers

PMID41892226

DOI10.3390/biology15060466

PMCPMC13023884

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.