Ultrasensitive Microfiber Biosensor with Synergistic Sensitization of Gold Nanoparticles and Two-Dimensional Material Black Phosphorus for Detection of BRCA1 Gene Synthetic Sequence.

Lina Wang, Duo Yi, Youfu Geng, Xuejin Li, Chong Li, Junyu Niu

Abstract read

In one paragraph

Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Lina WangCollege of Electronic Engineering, Huainan Normal University, Huainan 232038, China.

Duo YiShenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China.

Youfu GengShenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-0019-3813

Xuejin LiShenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China.

Chong LiCollege of Electronic Engineering, Huainan Normal University, Huainan 232038, China.

Junyu NiuXi'an Structure-Function Materials International Science and Technology Cooperation Base, School of Materials and Chemical Engineering, Xi'an Technological University, Xi'an 710021, China.

Funding

Anhui Province College Student Innovation Training Program Project S201410381003Horizontal fund Project of Huainan Normal University 724485National Natural Science Foundation of China 51808347Scientific Research Initiation Grant Project of Huainan Normal University 823064Shenzhen Basic Research Project JCYJ20220531103007016Stabilization Support Program for Higher Education Institutions of Shenzhen 20200811232156001

6 · The paper itself

Abstract

Sensitive quantitative detection of breast cancer gene synthetic sequences is crucial for related biosensing research. To address the limitations of traditional sensors for detecting ultra-low concentrations, this study developed a novel fiber-optic biosensor by combining nanomaterial sensitization with nanoparticle signal amplification strategies. A fiber optic sensor based on single-mode fiber-thin-core fiber-multimode fiber-single-mode fiber structure was fabricated and functionalized with black phosphorus (BP) nano-interface. The Au@cDNA complex was prepared by covalently immobilizing sulfhydryl-modified complementary DNA (cDNA) on the surface of gold nanoparticles (AuNPs). The complex specifically hybridized with the probe DNA (pDNA) immobilized on the surface of the sensor. The experimental results show that this sensor has a sensitivity of 0.793 nm/lgM and a detection limit of 20.27 fM in the concentration range of 100 fM to 100 nM. Specifically, the BP-functionalized sensor exhibits superior dynamic range, higher sensitivity, and lower detection limits for detecting Au@cDNA. The synergistic effect of interfacial sensitization by BP and signal amplification by AuNPs significantly enhances detection performance, providing a promising platform for ultra-sensitive biosensing applications.

Indexed as

Biosensing TechniquesGenes, BRCA1Metal NanoparticlesFiber Optic TechnologyGoldHumansLimit of DetectionPhosphorusGoldPhosphorusblack phosphorus nano-interfacebreast cancer genesgold nanoparticlesmicrofiber biosensorsignal amplification

Identifiers

PMID41892057

DOI10.3390/bios16030165

PMCPMC13024694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.