Evidence map›Paper›PMID 41892048›Full record

ArticleBiosensors2026

A Chemiresistive Nanosensor Array for Rapid and Sensitive VOC-Based Detection and Differentiation of Prosthetic Joint Infection-Relevant Pathogens in Enriched Human Synovial Fluid.

Derese Getnet, Taejun Ko, Deyu Liu, Buyu Yeh, Jennifer Dootz, Venkatasivasai Sujith Sajja, Subramaniam Somasundaram, Mya Wilkes, Krista Toler, Robert Hopkins and 1 more

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In one paragraph

Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Derese GetnetTao Treasures LLC (d/b/a NanoBioFAB), Frederick, MD 21703, USA.ORCID 0000-0002-2619-4910
Taejun KoTao Treasures LLC (d/b/a NanoBioFAB), Frederick, MD 21703, USA.ORCID 0000-0001-8763-445X
Deyu LiuTao Treasures LLC (d/b/a NanoBioFAB), Frederick, MD 21703, USA.ORCID 0000-0002-2578-9525
Buyu YehTao Treasures LLC (d/b/a NanoBioFAB), Frederick, MD 21703, USA.
Jennifer DootzTao Treasures LLC (d/b/a NanoBioFAB), Frederick, MD 21703, USA.
Venkatasivasai Sujith SajjaTao Treasures LLC (d/b/a NanoBioFAB), Frederick, MD 21703, USA.ORCID 0000-0002-1992-9501
Subramaniam SomasundaramDepartment of Diagnostics Research and Development, Zimmer Biomet, Warsaw, IN 46580, USA.ORCID 0000-0002-1064-4358
Mya WilkesDepartment of Diagnostics Research and Development, Zimmer Biomet, Warsaw, IN 46580, USA.ORCID 0009-0000-1489-0882
Krista TolerDepartment of Diagnostics Research and Development, Zimmer Biomet, Warsaw, IN 46580, USA.ORCID 0000-0001-9683-8710
Robert HopkinsTao Treasures LLC (d/b/a NanoBioFAB), Frederick, MD 21703, USA.ORCID 0000-0001-6102-6595
Xiaonao LiuTao Treasures LLC (d/b/a NanoBioFAB), Frederick, MD 21703, USA.ORCID 0000-0003-0078-1786

Funding

This research was partially supported by the U.S. Army Medical Research & Development Command (USAMRDC) and SBIR Office under Contract Number: (DHA SBIR HT942525CE008, HT942525CE045, HT942525C0013, HT942525CE018, HT942523C0045, W81XWH21C008). Remnant syno DHA SBIR HT942525CE008, HT942525CE045, HT942525C0013, HT942525CE018, HT942523C0045, W81XWH21C008
6 · The paper itself

Abstract

Rapid and actionable pathogen identification remains a major unmet need in the diagnosis of prosthetic joint infection (PJI). Current diagnostic approaches either provide rapid host response information without pathogen specificity or identify pathogens with delays of days to weeks. Here, we report a chemiresistive nanosensor array combined with machine learning analysis for same-day, pathogen-specific detection based on volatile organic compound (VOC) profiling. A 19-channel nanosensor array was first validated in vitro against a panel of ESKAPEE pathogens, achieving 96% mean classification accuracy using a radial-basis-function support vector machine (SVM) classifier. Data-driven optimization yielded a reduced six-sensor array with high signal-to-noise performance. The optimized platform was evaluated using pooled, uninfected human synovial fluid enriched 1:1 with nutrient media and spiked with

Indexed as

Biosensing TechniquesProsthesis-Related InfectionsSynovial FluidVolatile Organic CompoundsHumansMachine LearningPseudomonas aeruginosaStaphylococcus aureusStaphylococcus epidermidisVolatile Organic Compoundsbiosensorchemiresistive nanosensor arrayelectronic nosemachine learningpoint-of-careprosthetic joint infectionrapid detectionsensitive detectionsupport vector machinesynovial fluidVOC profiling

Identifiers

PMID41892048
PMCPMC13023655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.