ArticleDiseases (Basel, Switzerland)2026
Global Mortality from Severe Infectious Diseases Among Adolescents Aged 10-19 Years, 1990-2023: Long-Term Trends and Cause Composition from the Global Burden of Disease 2023 Study.
Article in Diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Challenges identified from trends in mortality among patients with gastrointestinal cancer in the United States.Journal of gastrointestinal oncology · 2026Article
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Abstract
backgroundSevere infectious diseases remain a preventable cause of adolescent mortality worldwide, yet global evidence focused on adolescence as a distinct life-course stage-and its vulnerability to health system disruption-remains limited. We examined long-term mortality rate trends, cause composition, and COVID-19-related changes among adolescents compared with late childhood.
methodsWe analyzed Global Burden of Disease 2023 mortality estimates from 1990 to 2023 for six acute severe infectious causes: lower respiratory infections, meningitis, encephalitis, diarrhoeal diseases, typhoid/paratyphoid fever, and COVID-19. Analyses focused on adolescents aged 10-19 years, with children aged 5-9 years as a comparator. Mortality rates (per 100,000 population) were the primary metric. Trends were quantified using estimated annual percentage change (EAPC), and pre-COVID, COVID peak, and post-COVID periods were compared across Socio-demographic Index (SDI) categories.
resultsFrom 1990 to 2023, mortality rates declined globally across all age groups; however, reductions among adolescents were consistently slower than those among children aged 5-9 years (EAPC -2.27% vs. -3.55% per year). Diarrhoeal diseases and typhoid/paratyphoid fever exhibited the steepest long-term declines, whereas lower respiratory infections and meningitis demonstrated slower reductions and maintained a substantial share of adolescent mortality risk. During the COVID-19 peak, mortality rates modestly increased among adolescents, while children continued their gradual decline. Mortality rates remained highest in low-SDI settings.
conclusionsDespite substantial global progress, severe infectious diseases continue to impose significant and inequitable mortality risk among adolescents. The persistence of a concentrated cause profile and the amplification of mortality during system disruption underscore adolescence as a vulnerable life-course stage requiring sustained prevention and resilient acute care systems.
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