Evidence map›Paper›PMID 41891949›Full record

ArticleThe Journal of physiology2026

Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle.

Chad M Skiles, Zachary J Fennel, Paul-Emile Bourrant, Elena M Yee, Robert J Castro, Hannah A Zabriskie, Melina Itinose, Mark A Supiano, Ryan M O'Connell, Micah J Drummond

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chad M SkilesDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.
Zachary J FennelDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.
Paul-Emile BourrantDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Elena M YeeDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Robert J CastroDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Hannah A ZabriskieDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.
Melina ItinoseDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.
Mark A SupianoDepartment of Internal Medicine, Division of Geriatrics, Center on Aging, University of Utah, Salt Lake City, UT, USA.
Ryan M O'ConnellDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT, USA.
Micah J DrummondDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.

Funding

Interdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8M
Regulation of macrophage metabolism in aged muscle during recoveryR01AG076075 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Micah J Drummond, Ryan M O'Connell · 2022 to 2026
$3.3M
American Heart Association-American Stroke Association AHA_25PRE1362056NIA NIH HHS R01 AG076075NIDDK NIH HHS T32 DK091317
6 · The paper itself

Abstract

Immune cells are critical for modulating inflammation and extracellular matrix remodelling for effective muscle regrowth following disuse atrophy. However, disrupted macrophage function and accumulation of cellular senescence may limit muscle recovery in ageing. The present study aimed to compare changes in the cellular dynamics of muscle macrophages, cellular senescence and collagen content during early recovery following 14 days of unilateral limb immobilization in young (n = 18; ∼24 years) and older male and female adults (n = 18; ∼69 years). Participants underwent 14 days of immobilization followed by 7 days of re-ambulation. Muscle biopsies were collected at baseline, post-immobilization, and at 2 and 7 days of recovery. During re-ambulation, older adults exhibited elevated immune cell infiltration (haematoxylin and eosin, CD45

Indexed as

AgingCellular SenescenceImmobilizationMacrophagesMuscle, SkeletalAdultAgedAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeCollagenFemaleHumansLectins, C-TypeMaleMannose-Binding LectinsAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 antigen, humanCD68 MoleculeCollagenLectins, C-TypeMannose-Binding LectinsMannose ReceptorReceptors, Cell Surfaceageingdisuse atrophyfibrosisimmunosenescenceinflammation

Identifiers

PMID41891949
PMCPMC13082186

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.