Evidence map›Paper›PMID 41891948›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2026

Mechanistic Insights into Protein Corona Formation: The Surface Charge of Mesoporous Silica Nanoparticles Determines the Orientation and the Conformation of Adsorbed BSA Protein.

Alessandra Ballicu, Gaia M Meloni, Matteo Farci, Davide Tocco, Marco Piludu, Drew F Parsons, Cristina Carucci, Barbara Jachimska, Andrea Salis

Erratum issuedAbstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Alessandra BallicuDepartment of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554 bivio Sestu, Monserrato (CA) 09042, Italy.
Gaia M MeloniDepartment of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554 bivio Sestu, Monserrato (CA) 09042, Italy.ORCID 0009-0004-0938-8248
Matteo FarciDepartment of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554 bivio Sestu, Monserrato (CA) 09042, Italy.ORCID 0000-0001-9538-2344
Davide ToccoCenter for Colloid and Surface Science, via della Lastruccia 3, Sesto Fiorentino (FI) I-50019, Italy.ORCID 0000-0001-7364-9167
Marco PiluduCenter for Colloid and Surface Science, via della Lastruccia 3, Sesto Fiorentino (FI) I-50019, Italy.ORCID 0000-0003-1917-0475
Drew F ParsonsDepartment of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554 bivio Sestu, Monserrato (CA) 09042, Italy.ORCID 0000-0002-3956-6031
Cristina CarucciDepartment of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554 bivio Sestu, Monserrato (CA) 09042, Italy.ORCID 0000-0001-8660-788X
Barbara JachimskaJerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Krakow 30-239, Poland.ORCID 0000-0002-2445-7318
Andrea SalisDepartment of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554 bivio Sestu, Monserrato (CA) 09042, Italy.ORCID 0000-0001-5746-2693

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of the protein corona critically governs the biological identity of nanoparticles, but the molecular determinants of protein orientation and conformational fate remain elusive. Here, we examine the adsorption of bovine serum albumin (BSA), a prototypical dysopsonin, onto bare and amino-functionalized mesoporous silica nanoparticles (MSN and MSN-NH

Indexed as

NanoparticlesProtein CoronaSerum Albumin, BovineSilicon DioxideAdsorptionAnimalsCattleParticle SizePorosityProtein ConformationSurface PropertiesProtein CoronaSerum Albumin, BovineSilicon Dioxide

Identifiers

PMID41891948
PMCPMC13063808

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.