Evidence map›Paper›PMID 41891831›Full record

ArticleeLife2026

Nociceptor neurons control pollution-mediated neutrophilic asthma.

Jo-Chiao Wang, Amelia Kulle, Theo Crosson, Amin Reza Nikpoor, Surbhi Gupta, Anais Roger, Moutih Rafei, Ajitha Thanabalasuriar, Sebastien Talbot

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Basophils activate oncostatin M receptor-expressing vagal sensory neurons.The Journal of allergy and clinical immunology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jo-Chiao WangDepartment of Pharmacology and Physiology, University de Montreal, Montreal, Canada.ORCID https://orcid.org/0000-0003-0122-4500
Amelia KulleDepartment of Microbiology and Immunology, McGill University, Montreal, Canada.
Theo CrossonDepartment of Pharmacology and Physiology, University de Montreal, Montreal, Canada.
Amin Reza NikpoorDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
Surbhi GuptaDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
Anais RogerDepartment of Pharmacology and Physiology, University de Montreal, Montreal, Canada.
Moutih RafeiDepartment of Pharmacology and Physiology, University de Montreal, Montreal, Canada.
Ajitha ThanabalasuriarDepartment of Microbiology and Immunology, McGill University, Montreal, Canada.ORCID https://orcid.org/0000-0001-6281-3013
Sebastien TalbotDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.ORCID https://orcid.org/0000-0001-9932-7174

Funding

Intra-tumoral neurons contribute to head and neck cancer painR01DE032712 · NIDCR · SANFORD RESEARCH/USD · PI Paola Drapkin Vermeer · 2023 to 2026
$1.8M
Canadian Cancer Society Emerging Scholar Research Grant 708096Canadian Foundation for Innovation 44135Canadian Institute of Health Research 186176CIHR 193741CIHR 407016CIHR 461274CIHR 461275Knut and Alice Wallenberg Foundation KAW 2021.0141Knut and Alice Wallenberg Foundation KAW 2022.0327Natural Sciences and Engineering Research Council of Canada RGPIN-2019-06824NIH/NIDCR R01DE032712Swedish Research Council 2022-01661
6 · The paper itself

Abstract

The immune and sensory nervous systems, having evolved in parallel, communicate through shared receptors and transmitters to maintain homeostasis and respond to both external and internal disruptions. Although neural responses often confer protective benefits, they can also exacerbate inflammation during allergic reactions such as asthma. In our study, we modeled pollution-exacerbated asthma by exposing mice to ambient PM

Indexed as

AsthmaNeutrophilsNociceptorsParticulate MatterAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalLungMiceMice, Inbred C57BLOvalbuminTRPA1 Cation ChannelTRPV Cation ChannelsOvalbuminParticulate MatterTRPA1 Cation ChannelTrpa1 protein, mouseTRPV1 protein, mouseTRPV Cation Channelsasthmaimmunologyinflammationlung inflammationmouseneuro-immunologyneutrophilnociceptor neuronspollution

Identifiers

PMID41891831
PMCPMC13030891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.