Evidence map›Paper›PMID 41891822›Full record

ArticleRadiology. Imaging cancer2026

TumorSynth: Integrated Brain Tumor and Tissue Segmentation on Brain MRI Scans of Any Resolution and Contrast.

Jiaming Wu, Benjamin Billot, Fenqiang Zhao, Junjie Li, Yaou Liu, Zhizheng Zhuo, Giuseppe Pontillo, Xing Liu, Song Lin, Xiaokang Zhang and 7 more

Abstract read
In one paragraph

Article in Radiology. Imaging cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiaming WuUCL Hawkes Institute, University College London, 90 High Holborn, London WC1V 6LJ, United Kingdom.ORCID 0000-0003-0783-0026
Benjamin BillotComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Mass.
Fenqiang ZhaoDAMO Academy, Alibaba Group, Hangzhou, China.
Junjie LiDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yaou LiuDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-4352-5774
Zhizheng ZhuoDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-6635-8705
Giuseppe PontilloUCL Hawkes Institute, University College London, 90 High Holborn, London WC1V 6LJ, United Kingdom.
Xing LiuDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Song LinDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaokang ZhangDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jun QiuDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jinyuan WengUCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Ling ZhangDAMO Academy, Alibaba Group, Hangzhou, China.
Le LuDAMO Academy, Alibaba Group, Hangzhou, China.
Juan Eugenio IglesiasUCL Hawkes Institute, University College London, 90 High Holborn, London WC1V 6LJ, United Kingdom.
Frederik BarkhofUCL Hawkes Institute, University College London, 90 High Holborn, London WC1V 6LJ, United Kingdom.
Ferran Prados CarrascoUCL Hawkes Institute, University College London, 90 High Holborn, London WC1V 6LJ, United Kingdom.

Funding

Functionally guided adult whole brain cell atlas in human and NHPUM1MH130981 · NIMH · ALLEN INSTITUTE · PI Ed Lein, Hongkui Zeng · 2022 to 2026
$91.9M
Acquisition-independent machine learning for morphometric analysis of underrepresented aging populations with clinical and low-field brain MRIRF1AG080371 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Juan Eugenio Iglesias Gonzalez · 2023 to 2026
$4.0M
Portable, Low Field Brain Magnetic Resonance Imaging (MRI) for Acute StrokeR01EB031114 · NIBIB · YALE UNIVERSITY · PI William Taylor Kimberly, Matthew Scot Rosen · 2022 to 2026
$3.5M
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanningR01AG070988 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI IGLESIAS GONZALEZ, JUAN EUGENIO · 2021 to 2025
$2.7M
Open-source software for multi-scale mapping of the human brainRF1MH123195 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE, IGLESIAS GONZALEZ, JUAN EUGENIO · 2020 to 2020
$2.0M
Measuring Brain Health Using Low-Field Portable MRIR21NS138995 · NINDS · YALE UNIVERSITY · PI DE HAVENON, ADAM H. · 2024 to 2024
$477k
NIA NIH HHS R01 AG070988NIA NIH HHS RF1 AG080371NIBIB NIH HHS R01 EB031114NIMH NIH HHS RF1 MH123195NIMH NIH HHS UM1 MH130981NINDS NIH HHS R21 NS138995
6 · The paper itself

Abstract

Purpose To develop and validate a deep neural network that simultaneously segments brain tumors and anatomic structures, regardless of the contrast and resolution of the input scans, and can effortlessly adapt to unseen modalities. Materials and Methods The authors included various MRI scans from patients with and without brain tumors from four different datasets. Patient data were divided into a training set and a test set. The authors' method, TumorSynth, combines a Bayesian generative model and a deep learning segmentation model. The generative model creates paired synthetic labels and images with simulated tumors and brain tissues, providing a rich dataset for training the segmentation model. The authors quantitatively compared its performance with that of other widely used methods by calculating Dice similarity coefficients (DSCs). Results A total of 1971 patients with and without tumors were included in the study (training set,

Indexed as

Brain NeoplasmsDeep LearningImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMagnetic Resonance ImagingAdultBayes TheoremBrainFemaleHumansMaleMiddle AgedNeural Networks, ComputerCNSDeep LearningNeuro-OncologyNeurosurgerySegmentation

Identifiers

PMID41891822
PMCPMC13036690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.