Evidence map›Paper›PMID 41891813›Full record

ArticleeLife2026

Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration.

Bogdan Beirowski, Haoran Huang, Elisabetta Babetto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Bogdan BeirowskiDepartment of Neurology, The Neuroscience Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, United States.ORCID https://orcid.org/0000-0002-1241-1777
Haoran HuangDepartment of Neurology, The Neuroscience Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, United States.ORCID https://orcid.org/0000-0001-6125-5996
Elisabetta BabettoDepartment of Neurology, The Neuroscience Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, United States.ORCID https://orcid.org/0000-0002-6385-8288

Funding

Energizing and Protecting Axons Through Metabolic Coupling to Schwann CellsR01NS123450 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Elisabetta Babetto, Bogdan Beirowski · 2021 to 2026
$1.9M
NINDS NIH HHS R01 NS123450NINDS NIH HHS R01NS123450
6 · The paper itself

Abstract

Axon degeneration (AxD), accompanied by glial remodeling, is a pathological hallmark of many neurodegenerative diseases, leading to the disruption of neuronal connectivity. Understanding the mechanisms in neurons and glia that regulate AxD is essential for developing therapeutic strategies to prevent or mitigate axon loss. Wallerian degeneration (WD) is a well-established model to study the mechanisms of nerve injury-induced AxD, glial responses, and axon-glia interactions. We recently showed that Schwann cells (SCs), the axon-associated glia of the peripheral nervous system, exert protective effects on axons through their rapid metabolic injury response. Enhancing this SC response promotes axon protection during WD. A prior study reported that eliminating the orphan tumor necrosis factor receptor DR6 (death receptor 6, encoded by

Indexed as

AxonsReceptors, Tumor Necrosis FactorSchwann CellsWallerian DegenerationAnimalsMiceMice, KnockoutReceptors, Tumor Necrosis FactorTnfrsf21 protein, mousecell biologyc-Jungliamousenerveneurosciencereprogramming

Identifiers

PMID41891813
PMCPMC13030889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.